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Springer Theses

Dual-Mode Electro-photonic Silicon Biosensors

Authors: José, Juan-Colás

  • Nominated as an outstanding PhD thesis by the University of York, UK
  • Demonstrates the first integration of silicon photonics with electrochemistry to yield a single, innovative and powerful technology
  • Includes discussion of the key findings that were published in Nature Communications
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eBook $99.00
price for USA (gross)
  • ISBN 978-3-319-60501-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $129.00
price for USA
  • ISBN 978-3-319-60500-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This highly interdisciplinary thesis reports on two innovative photonic biosensors that combine multiple simultaneous measurements to provide unique insights into the activity and structure of surface immobilized biological molecules. In addition, it presents a new silicon photonic biosensor that exploits two cascaded resonant sensors to provide two independent measurements of a biological layer immobilized on the surface. By combining these two measurements, it is possible to unambiguously quantify the density and thickness of the molecular layer; here, the approach’s ability to study molecular conformation and conformational changes in real time is demonstrated.
The electrophotonic biosensor integrates silicon photonics with electrochemistry into a single technology. This multi-modal biosensor provides a number of unique capabilities that extend the functionality of conventional silicon photonics. For example, by combining the complementary information revealed by simultaneous electrochemical and photonic measurements, it is possible to provide unique insights into on-surface electrochemical processes. Furthermore, the ability to create electrochemical reactions directly on the silicon surface provides a novel approach for engineering the chemical functionality of the photonic sensors. The electrophotonic biosensor thus represents a critical advance towards the development of very high-density photonic sensor arrays for multiplexed diagnostics.

Table of contents (7 chapters)

  • Preamble

    Juan Colás, José

    Pages 1-6

  • Introduction to Label-Free Biosensing

    Juan Colás, José

    Pages 7-35

  • Fabrication and Experimental Techniques

    Juan Colás, José

    Pages 37-57

  • The Electro-Photonic Silicon Biosensor

    Juan Colás, José

    Pages 59-93

  • Study and Application of Electrografted Layers of Diazonium Ions

    Juan Colás, José

    Pages 95-118

Buy this book

eBook $99.00
price for USA (gross)
  • ISBN 978-3-319-60501-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $129.00
price for USA
  • ISBN 978-3-319-60500-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Dual-Mode Electro-photonic Silicon Biosensors
Authors
Series Title
Springer Theses
Copyright
2017
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG
eBook ISBN
978-3-319-60501-2
DOI
10.1007/978-3-319-60501-2
Hardcover ISBN
978-3-319-60500-5
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XV, 149
Number of Illustrations and Tables
16 b/w illustrations, 89 illustrations in colour
Topics