Biomarkers for Endometriosis

1. Front Matter

   Pages i-xii

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2. Building Translational Research Infrastructure and Access to Expertise for Biomarker Discovery in Cancer

   • Jacqueline A. Hall

   Pages 1-25

3. Biomarkers of Endometrial Cancer

   • Nicholas Galazis

   Pages 27-39

4. Biomarker Development in Chronic Inflammatory Diseases

   • Aristeidis H. Katsanos, Kalliroi Kyriakidi, Fotini B. Karassa, Dimitrios Politis, Alexandros Skamnelos, Dimitrios K. Christodoulou et al.

   Pages 41-75

5. Endometriosis and Diagnostic Delay: The Patient’s Perspective

   • Silke Apers, Eline A. F. Dancet, Thomas D’Hooghe

   Pages 77-82

6. Genetic Biomarkers for Endometriosis

   • Sang Hong Lee, Yadav Sapkota, Jenny Fung, Grant W. Montgomery

   Pages 83-93

7. Epidemiological and Clinical Risk Factors for Endometriosis

   • Leslie V. Farland, Divya K. Shah, Marina Kvaskoff, Krina T. Zondervan, Stacey A. Missmer

   Pages 95-121

8. Peripheral Blood Biomarkers for Endometriosis

   • Amelie Fassbender, Dorien O, Christian M. Becker, Thomas D’Hooghe

   Pages 123-139

9. Biomarkers for Endometriosis in Saliva, Urine, and Peritoneal Fluid

   • Ndeye-Aicha Gueye, Jamie Stanhiser, Lindsey Valentine, Alexander Kotlyar, Linnea Goodman, Tommaso Falcone

   Pages 141-163

10. mRNA and miRNA Biomarkers for Endometriosis

    • Lusine Aghajanova, R. O. Burney, N. D. Tran, Linda C. Giudice

    Pages 165-183

11. Proteomic Biomarkers for Endometriosis

    • Amelie Fassbender, Antoine Hubert, Etienne Waelkens, Dorien O, Thomas D’Hooghe

    Pages 185-198

12. Harmonization of Clinical and Laboratory Data to Improve Biomarker Discovery in Endometriosis: WERF EPHect

    • Nilufer Rahmioglu, Amelie Fassbender, Allison Vitonis, Lone Hummelshoj, David Adamson, Christian M. Becker et al.

    Pages 199-226

13. OMICs Studies and Endometriosis Biomarker Identification

    • Merli Saare, Maire Peters, Alar Aints, Triin Laisk-Podar, Andres Salumets, Signe Altmäe

    Pages 227-258

14. Back Matter

    Pages 259-267

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This book presents an overview of the diagnostic performance of non- or semi-invasive tests for endometriosis in peripheral blood, endometrium, saliva, peritoneal fluid and urine. The value of existing and emerging systems biology technologies for biomarker development is addressed in several chapters on genetics, microarrays, proteomics and metabolomics. Although tests with high sensitivity and acceptable specificity have been developed, sometimes validated in independent populations and seem promising, more research is needed to translate these data into clinical benefit for patients and coordinate efforts internationally to standarize analysis, reports and operating procedures. The gold standard to diagnose endometriosis is currently through laparoscopic inspection with histological confirmation, a surgical procedure with rare but significant potential risks for the patients. A non-invasive test for endometriosis would be critical for the early detection of endometriosis of symptomatic women with pelvic pain and/or subfertility with normal ultrasound. This would include nearly all cases of minimal-mild endometriosis, some cases of moderate-severe endometriosis without a clearly visible ovarian endometrioma and cases with pelvic adhesions and/or other pelvic pathology, who might benefit from surgery to improve pelvic pain and/or subfertility. Such a test would also be useful in symptomatic women with ultrasound imaging suspicious for endometriosis, since it may be difficult to differentiate an ovarian endometrioma from other ovarian cysts and since the quality of ultrasound imaging is highly variable worldwide.

• Biomarker development
• Endometrial biomarkers
• Endometriosis
• Proteomic biomarkers
• Genetic biomarkers
• Metabolomics

• Department of Development and Regeneration Organ Systems, Group Biomedical Sciences, KU Leuven (University of Leuven), Leuven, Belgium

  Thomas D'Hooghe

Thomas M. D’Hooghe is Professor of Reproductive Medicine in the Deparment of  Development and Regeneration of the Biomedical Sciences Group at KU Leuven (University of Leuven), Belgium. Dr. D’Hooghe is also Professor Adjunct, Department of Obstetrics, Gynecology and Reproductive Medicine, Yale University Medical School, New Haven, Connecticut, USA, and Editor-in-Chief of Gynecologic and Obstetric Investigation,Basel, since 2002. Since October 2015, Professor D’Hooghe is the Vice-President and Head of Global Medical Affairs Fertility in the Department of Research and Development at Merck KGaA, Darmstadt, Germany.

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