Development of the Cerebellum from Molecular Aspects to Diseases

1. Front Matter

   Pages i-ix

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2. The Development of the Cerebellum: From the Beginnings

   • Jan Voogd

   Pages 1-32

3. The Embryology and Anatomy of the Cerebellum

   • Maryam Rahimi Balaei, Niloufar Ashtari, Hugo Bergen

   Pages 33-43

4. Cellular and Genetic Programs Underlying Cerebellum Development

   • Alexandra L. Joyner, Ryan Willett, Andrew Lawton

   Pages 45-65

5. Early Purkinje Cell Development and the Origins of Cerebellar Patterning

   • Filippo Casoni, Laura Croci, Ottavio Cremona, Richard Hawkes, G. Giacomo Consalez

   Pages 67-86

6. Cerebellar Developmental Disorders and Cerebellar Nuclei

   • Hong-Ting Prekop, Alessio Delogu, Richard J. T. Wingate

   Pages 87-104

7. Motor Circuit Abnormalities During Cerebellar Development

   • Elizabeth P. Lackey, Roy V. Sillitoe

   Pages 105-127

8. Developmental Disorders of the Cerebellum and Neurotrophic Factors

   • Leila Pirmoradi, Ali Akbar Owji, Shahla Shojaei

   Pages 129-151

9. Apoptosis, Autophagy, and Unfolded Protein Response and Cerebellar Development

   • Mohammad Amin Moosavi, Marveh Rahmati, Niloufar Ashtari, Javad Alizadeh, Mohammad Hashemi, Seyedeh Zahra Bathaei et al.

   Pages 153-178

10. The Ubiquitin Proteasome System and Cerebellar Developmental Disease

    • Jerry Vriend, Xiaodan Jiao

    Pages 179-196

11. Epigenetics and Cerebellar Neurodevelopmental Disorders

    • Mojgan Rastegar

    Pages 197-218

12. Hormonal Regulation of Cerebellar Development and Its Disorders

    • Noriyuki Koibuchi

    Pages 219-235

13. Infections of the Cerebellum

    • Kevin M. Coombs

    Pages 237-253

14. Neuroimmune Mechanisms of Cerebellar Development and Its Developmental Disorders: Bidirectional Link Between the Immune System and Nervous System

    • Nour Eissa, Laëtitia Kermarrec, Jean-Eric Ghia

    Pages 255-274

15. Teratogenic Influences on Cerebellar Development

    • Albert E. Chudley

    Pages 275-300

16. Primary Pediatric Brain Tumors of the Posterior Fossa: Part I

    • Kathleen Felton, Amanda Hogg, Lisa Liang, Christopher Aiken, Thomas Klonisch, Frank van Landeghem et al.

    Pages 301-326

17. Primary Pediatric Brain Tumors of the Posterior Fossa Part II: A Comprehensive Overview of Medulloblastoma

    • Lisa Liang, Christopher Aiken, Kathleen Felton, Amanda Hogg, Frank van Landeghem, T. Klonisch et al.

    Pages 327-351

18. Can Cerebellar Neurodevelopmental Disorders Affect Behavioral Disorders or Vice Versa?

    • Seyed Soheil Saeedi Saravi, Ahmad Reza Dehpour

    Pages 353-367

19. Neurodevelopmental Disorders of the Cerebellum: Autism Spectrum Disorder

    • Mehnosh Toback, Kambiz Zangeneh, Tabrez J. Siddiqui, Hassan Marzban

    Pages 369-387

20. Clinical Aspects of the Inherited Cerebellar Malformations

    • Asghar Marzban, Mohammad Vafaee-shahi, Kamran Azarkhish

    Pages 389-406

The authors present the most current and cutting-edge knowledge regarding the molecular basis of cerebellar development, focusing on information relevant to laboratory scientists and clinicians providing service to patients with cerebellar disorders. Knowledge obtained from advanced neuroimaging techniques that are used during development, and from molecular- and genetic-based studies has provided rapidly-growing evidence that the cerebellum is a brain region that is highly impacted by developmental defects. Cerebellar defects result in significant intellectual and motor function impairment that affects both the patients and their families.

• cerebellum
• cerebellar growth and development
• neurological disorder
• diagnosis
• management

• Department of Human Anatomy and Cell Science, The Children’s Hospital Research Institute of Manitoba (CHRIM), Max Rady College of Medicine, Rady Faculty of Health Science, University of Manitoba, Winnipeg, Canada

  Hassan Marzban

Dr. Hassan Marzban (Editor) is a human anatomist and cerebellar developmental biologist, at Department of Human Anatomy and Cell Sciences,  the College of Medicine, Faculty of Health Sciences, University of Manitoba. Dr. Marzban is a pioneer in the field and his research is focused to understand the cellular and molecular mechanisms of the developing cerebellum and neurodevelopmental disorders and disabilities.

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