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Current Topics in Microbiology and Immunology

Uptake and Trafficking of Protein Toxins

Editors: Barth, Holger (Ed.)

  • Provides new insights into the development of tailored transport systems for the targeted drug delivery into mammalian cells
  • Reviews the key recent research on the role of cellular receptors, toxin pores and host cell chaperones for the uptake of bacterial protein toxins into cells
  • Promotes the development of novel pharmacological strategies to protect cells from intoxication  
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eBook $149.00
price for USA (gross)
  • ISBN 978-3-319-58893-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-3-319-58891-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of Clostridium botulinum neurotoxins, Clostridium botulinum C3 toxin, Clostridium difficile toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin. In brief, specific binding/transport (B) subunits deliver the enzyme (A) subunits into the cytosol, where the latter modify their substrates, producing cytotoxic effects and the characteristic toxin-associated diseases. Key mechanisms for the transport of the A subunits from endosomes into the cytosol and the role of trans-membrane pores formed by the B subunits and host cell chaperones for this process are reviewed. The book’s closing chapters focus on compounds which inhibit the transport of the A subunits from endosomes into the cytosol and therefore might lead to novel therapeutic strategies for toxin-associated diseases. These substances include pharmacological inhibitors of the host cell chaperones involved, as well as multivalent and heterocyclic molecules that specifically block the toxins’ translocation channels. This volume offers an up-to-date resource for scientists.

About the authors

Holger Barth

Institute of Pharmacology and Toxicology, University of Ulm Medical Center, Albert-Einstein-Allee 11, 89081 Ulm, Germany, e-mail: holger.barth@uni-ulm.de

Table of contents (9 chapters)

  • Two Feet on the Membrane: Uptake of Clostridial Neurotoxins

    Rummel, Andreas

    Pages 1-37

  • Uptake of Clostridial Neurotoxins into Cells and Dissemination

    Connan, Chloé (et al.)

    Pages 39-78

  • Receptors and Binding Structures for Clostridium difficile Toxins A and B

    Gerhard, Ralf

    Pages 79-96

  • Cell Entry of C3 Exoenzyme from Clostridium botulinum

    Rohrbeck, Astrid (et al.)

    Pages 97-118

  • Receptor-Binding and Uptake of Binary Actin-ADP-Ribosylating Toxins

    Papatheodorou, Panagiotis (et al.)

    Pages 119-133

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-3-319-58893-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-3-319-58891-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Uptake and Trafficking of Protein Toxins
Editors
  • Holger Barth
Series Title
Current Topics in Microbiology and Immunology
Series Volume
406
Copyright
2017
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG
eBook ISBN
978-3-319-58893-3
DOI
10.1007/978-3-319-58893-3
Hardcover ISBN
978-3-319-58891-9
Series ISSN
0070-217X
Edition Number
1
Number of Pages
VII, 256
Topics