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Advances in Experimental Medicine and Biology

Store-Operated Ca²⁺ Entry (SOCE) Pathways

Emerging Signaling Concepts in Human (Patho)physiology

Editors: Groschner, Klaus, Graier, Wolfgang, Romanin, Christoph (Eds.)

  • Describes the role of SOCE pathways in health and disease
  • Combines basic research with clinical aspects
  • The second edition was updated with new discoveries in the field of structural biology, optogenetics and disease
  • Introduces the most recent concepts of linkage between SOCE and mitochondrial Ca2+ signaling
  • Gives insight into the newly identified molecular structure of the STIM-Orai machinery at the atomic resolution level
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Buy this book

eBook $219.00
price for USA (gross)
  • ISBN 978-3-319-57732-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.00
price for USA
  • ISBN 978-3-319-57731-9
  • with online files
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This second edition of the book on Store-operated Ca2+  Entry Pathways has been updated with the newest discoveries that emerged in the field within the last five years. The crystal structure of the Ca2+  signaling core complex is described which adds to a new understanding of the molecular interactions involved. Each chapter has been revised and extended. The book retains its interdisciplinary approach and supplies biochemists, cell biologists and biophysicists as well as clinicians in immunology, neurology and cardiology with valuable information on Ca2+  signaling mechanisms, functions, dysfunctions and their consequences.

About the authors

Prof. Klaus Groschner studied Pharmacy at the School of Pharmacy, University of Graz, Austria. He completed his PhD studies at the Department of Pharmacodynamics in Graz and received part of his postdoctoral education at the University of Miami, Florida, USA, studying electrophysiology and cell biology. In 1990 he became an Assistant Professor at the Department of Pharmacology and Toxicology and received his Habilitation in Pharmacology and Toxicology along with promotion to Associate Professor in 1993. Until 2011 he was head of a research unit for Physiology and Pharmacology of Membrane Transport at the Institute of Pharmaceutical Sciences at the University of Graz. Since 2012 he is Full Professor for Biophysics and Chairman at the Institute of Biophysics at the Medical University of Graz.

Prof. Wolfgang F. Graier studied Pharmacy at the University of Graz, Austria and received his PhD in Pharmacology at the Department of Pharmacology and Toxicology, University of Graz. In 1993, 1994 he was a postdoctoral research fellow, analyzing physiology and membrane biophysics at the Dalton Cardiovascular Research Center, University of Missouri, Columbia, USA. In 1994 he became an Assistant Professor at the Department of Medical Biochemistry, University of Graz. In 1995 he became Associate Professor (Habilitation) in Biochemical Pharmacology and in Physiology in 2001 at the Department of Medical Biochemistry, University of Graz. Since 2009 he is Full Professor for Molecular Biology and Chairman of the Institute of Molecular Biology and Biochemistry at the Medical University of Graz. Since 2015 he is also Head of the Nikon-Center of Excellence for Super-Resolution Microscopy: Cells & Organelles that is part of BioTechMed, the concerted research platform of the Medical University Graz, the University of Graz, and the Graz Technical University. In 2016 he co-founded a spin-off company named Next Generation Fluorescence Imaging, NGFI, (www.ngfi.eu).

 Prof. Christoph Romanin studied Chemistry at the Technical University of Graz, Austria and completed his doctoral studies at the Department of Pharmacology and Toxicology, University of Graz. In 1986 he started with a post-doc position at the Institute of Biophysics of the University of Linz, Austria, where he became Professor in Biophysics (Habilitation) in 1993 and served as an Associate Professor since 1997. In 2001 he was a guest researcher at the NIA, the National Institute on Aging of the NIH in Bethesda, USA. Currently, he is vice-chairman of the institute and head of the Ion Channel Group at the Institute of Biophysics in Linz, Austria.

Table of contents (31 chapters)

  • Introduction

    Putney, James W.

    Pages 3-13

  • The STIM-Orai Pathway: STIM-Orai Structures: Isolated and in Complex

    Zhu, Jinhui (et al.)

    Pages 15-38

  • The STIM-Orai Pathway: Orai, the Pore-Forming Subunit of the CRAC Channel

    Gudlur, Aparna (et al.)

    Pages 39-57

  • The STIM-Orai Pathway: The Interactions Between STIM and Orai

    Fahrner, Marc (et al.)

    Pages 59-81

  • The STIM-Orai Pathway: Conformational Coupling Between STIM and Orai in the Activation of Store-Operated Ca2+ Entry

    Nwokonko, Robert M. (et al.)

    Pages 83-98

Buy this book

eBook $219.00
price for USA (gross)
  • ISBN 978-3-319-57732-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.00
price for USA
  • ISBN 978-3-319-57731-9
  • with online files
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Store-Operated Ca²⁺ Entry (SOCE) Pathways
Book Subtitle
Emerging Signaling Concepts in Human (Patho)physiology
Editors
  • Klaus Groschner
  • Wolfgang Graier
  • Christoph Romanin
Series Title
Advances in Experimental Medicine and Biology
Series Volume
993
Copyright
2017
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG
eBook ISBN
978-3-319-57732-6
DOI
10.1007/978-3-319-57732-6
Hardcover ISBN
978-3-319-57731-9
Series ISSN
0065-2598
Edition Number
2
Number of Pages
XXIX, 645
Number of Illustrations and Tables
22 b/w illustrations, 62 illustrations in colour
Topics