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Drug and Gene Delivery to the Central Nervous System for Neuroprotection

Nanotechnological Advances

  • Book
  • © 2017

Overview

Editors:
  1. Hari S. Sharma

    1. International Experimental Central Nervous System Injury & Repair (IECNSIR), Laboratory of Cerebrovascular Biology, Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden

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  2. Dafin F. Muresanu

    1. Department of Clinical Neurosciences, University of Medicine and Pharmacy, Cluj-Napoca, Romania

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    You can also search for this editor in PubMed   Google Scholar

  3. Aruna Sharma

    1. International Experimental Central Nervous System Injury & Repair (IECNSIR), Laboratory of Cerebrovascular Biology, Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Broadens readers’ understanding of viral vector gene delivery to the brain for treating neurogenetic diseases targeted gene delivery into the brain using microbubble-facilitated focused ultrasound

  • Covers in detail the latest developments in delivering therapeutic materials, such as siRNA delivery to brain for treating neurological diseases, neuroprotective effects of gelatin nanoparticles in stroke, and nanowired drug delivery for brain diseases, heat stroke and CNS injury

  • Enriches understanding of new technologies for delivering therapeutic materials treating Alzheimer’s Disease, including targeted nanodrug delivery through the blood-brain barrier and the superior neuroprotective effects of nanowired drug delivery in Alzheimer’s Disease

  • Includes supplementary material: sn.pub/extras

  • Includes supplementary material: sn.pub/extras

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Table of contents (7 chapters)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. Renewable Biomaterials as Nanocarriers for Drug and Gene Delivery

    • Shimiao Zhang, Liejiang Jin, Muhammad Arshad, Aman Ullah
    Pages 1-32

  3. Nanocarriers as CNS Drug Delivery Systems for Enhanced Neuroprotection

    • Asya Ozkizilcik, Parker Davidson, Hulusi Turgut, Hari S. Sharma, Aruna Sharma, Z. Ryan Tian
    Pages 33-55

  4. Nanotechnology Based Approaches for Neurodegenerative Disorders: Diagnosis and Treatment

    • Sara Hernando, Enara Herran, Jose Luis Pedraz, Manoli Igartua, Rosa Maria Hernandez
    Pages 57-87

  5. Viral Vector Gene Delivery to the Brain for Treating Neurogenetic Diseases

    • Linnet Ramos, Jacqueline E. Hunter, John H. Wolfe
    Pages 89-125

  6. Sleep Deprivation Induced Blood-Brain Barrier Breakdown and Brain Pathology. Neuroprotective Effects of TiO2-Nanowired Delivery of Cerebrolysin and Ondansetron

    • Aruna Sharma, Dafin F. Muresanu, José Vicente Lafuente, Asya Ozkizilcik, Z. Ryan Tian, Anca D. Buzoianu et al.
    Pages 127-178

  7. Glyco-Functionalysed Biomaterials in Neuroregeneration

    • Laura Russo, Antonella Sgambato, Roberto Guizzardi, Simone Vesentini, Laura Cipolla, Francesco Nicotra
    Pages 179-198

  8. Targeting Nanoparticles to Brain: Impact of N-Methyl d-Aspartate Receptors

    • Ayse Basak Engin
    Pages 199-220

  9. Back Matter

    Pages 221-228
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Keywords

About this book

This book summarizes the latest research on drug and gene delivery to the central nervous system (CNS). The chapters address safety concerns regarding the nanotechnology that is needed to develop nanomedicine for clinical practice. Particular focus is given to new technologies that have emerged in recent years to deliver therapeutic materials, such as genes, drugs, and other agents using nanotechnologies of diverse origin. This is an ideal book for students, teachers, researchers, and clinicians interested in a deeper understanding of nanotechnological advances in therapeutic medicine.

This book also:

Broadens readers’ understanding of viral vector gene delivery to the brain for treating neurogenetic diseases as well as targeted gene delivery into the brain using microbubble-facilitated focused ultrasound

Covers in detail the latest developments in delivering therapeutic materials, such as siRNA delivery to the brain for treating neurological diseases, neuroprotective effects of gelatin nanoparticles in stroke, and nanowired drug delivery for brain diseases, heat stroke, and CNS injury

Enriches understanding of new technologies for delivering therapeutic materials treating Alzheimer’s Disease, including targeted nanodrug delivery through the blood-brain barrier and the superior neuroprotective effects of nanowired drug delivery in Alzheimer’s Disease

Editors and Affiliations

  • International Experimental Central Nervous System Injury & Repair (IECNSIR), Laboratory of Cerebrovascular Biology, Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden

    Hari S. Sharma, Aruna Sharma

  • Department of Clinical Neurosciences, University of Medicine and Pharmacy, Cluj-Napoca, Romania

    Dafin F. Muresanu

About the editors

Hari S. Sharma is a researcher in the Department of Surgical Sciences, Anesthesiology and Intensive Care at Uppsala University.

Dafin F. Muresanu is an Assistant Professor of Neurology at the Iuliu Hatieganu University of Medicine and Pharmacy.


Aruna Sharma is in the Department of Surgical Sciences, Anesthesiology and Intensive Care at Uppsala University.


Bibliographic Information

  • Book Title: Drug and Gene Delivery to the Central Nervous System for Neuroprotection

  • Book Subtitle: Nanotechnological Advances

  • Editors: Hari S. Sharma, Dafin F. Muresanu, Aruna Sharma

  • DOI: https://doi.org/10.1007/978-3-319-57696-1

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing AG 2017

  • Hardcover ISBN: 978-3-319-57695-4Published: 14 June 2017

  • Softcover ISBN: 978-3-319-86226-2Published: 12 August 2018

  • eBook ISBN: 978-3-319-57696-1Published: 05 June 2017

  • Edition Number: 1

  • Number of Pages: XIII, 228

  • Number of Illustrations: 9 b/w illustrations, 38 illustrations in colour

  • Topics: Neurosciences, Biomedical Engineering and Bioengineering, Neurobiology

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