Geriatric Oncology

1. Front Matter

   Pages i-xxxv

   PDF

2. Epidemiology and Public Health

   1. Front Matter

      Pages 1-1

      PDF

   2. Population Trends in Aging and Cancer

      • Lars Lund

      Pages 3-10

   3. Integrating Geriatric Oncology in Public Health Planning

      • Jeanne-Marie Bréchot, Philippe-Jean Bousquet, Claudia Ferrari, Jérôme Viguier, Norbert Ifrah

      Pages 11-21

   4. Healthcare Informatics and Technology in Managing the Older Cancer Patient

      • John Shen, Zhuoer Xie, Arash Naeim

      Pages 23-34

3. Biology of Aging and Cancer

   1. Front Matter

      Pages 35-35

      PDF

   2. Role of Cell Cycle Control, Checkpoints, and DNA Repair Mechanisms in Stem Cells and Changes with Aging and Cancerogenesis

      • Andreas Brown, Hartmut Geiger

      Pages 37-53

   3. Cellular Senescence and Tumor Promotion

      • Marco Demaria

      Pages 55-69

   4. Immunosenescence and Cancer Immunotherapy at Old Age: Basics

      • Tamas Fulop, Jacek M. Witkowski, K. Hirokawa, A. Larbi, G. Pawelec

      Pages 71-90

   5. Aging and Cancer Biology

      • Vladimir N. Anisimov

      Pages 91-109

   6. Chronic Mechanistic Target of Rapamycin Inhibition: Preventing Cancer to Delay Aging or Vice Versa?

      • Heather G. Hambright, Vincent Hurez, Tyler J. Curiel

      Pages 111-128

   7. Calpain-Calpastatin System in Lymphoid Neoplasm of the Aged

      • Jacek M. Witkowski, Anna Mikosik, Ewa Bryl, Tamas Fulop

      Pages 129-140

   8. The Biologic Interconnections Between Aging and Lymphoma

      • Claire Falandry, Clémentine Sarkozy, Gilles Salles

      Pages 141-152

   9. Aging of Natural Killer Cells in Acute Myeloid Leukemia

      • Beatriz Sanchez-Correa, Rafael Solana, Raquel Tarazona

      Pages 153-168

   10. Hematopoietic Stem Cell Aging and Malignant Hemopathies

       • Michele Goodhardt, David Garrick, Luan Dang, Adriano Salaroli, Dominique Bron

       Pages 169-181

   11. Mitochondria, Oxidative Stress, Cancer, and Aging

       • Simone Pecorini, Lara Gibellini, Sara De Biasi, Elena Bianchini, Milena Nasi, Andrea Cossarizza et al.

       Pages 183-204

4. (Patho)physiology of Aging and Cancer

   1. Front Matter

      Pages 205-205

      PDF

   2. Normal and Abnormal Aging (General Perspective for the Oncologist)

      • George E. Taffet

      Pages 207-213

   3. Respiratory Organ Aging and Cancer

      • Leah J. Witt, Carolyn J. Presley

      Pages 215-244

   4. Digestive Organ Aging and Cancer

      • Stéphane Gerard, Zara Steinmeyer, Stéphanie Lozano, Marie Garric, Philippe Girard, Loic Mourey et al.

      Pages 245-267

This book is intended as a comprehensive resource for clinicians and researchers seeking in-depth information on geriatric oncology. The coverage encompasses epidemiology, the biology and (patho)physiology of aging and cancer, geriatric assessment and management, hematologic malignancies, solid tumors, issues in patient care, and research methods.  

Since cancer is a disease of aging and people are living longer, most cancer patients are now aged 70 and older. Yet the more we age, the more diverse we become in terms of our health, biologic fitness, and cancer behavior. Typically, however, general oncology clinical trials address only a selected healthier and younger population of patients. Geriatric oncology is the area of oncology that addresses these issues but while a wealth of knowledge has been accumulated, information is often difficult to retrieve or insufficiently detailed. The SpringerReference program, in which this book is published, offers an ideal format for overcoming these limitations since it combines thorough coverage with access to living editions constantly updated chapter by chapter via a dynamic peer-review process, ensuring that information remains current and pertinent.

• Geriatric Oncology
• Cancer
• Elderly
• Biology of Aging and Cancer
• Comorbidity
• Treatment Decision Making

• Senior Adult Oncology Program, Moffitt Cancer Center, University of South Florida, Tampa, USA

  Martine Extermann

Dr. Martine Extermann is Professor of Oncology and Medicine at the University of South Florida. She is the Program Leader of the Senior Adult Oncology Program at the Moffitt Cancer Center. She earned her medical diploma and her medical Ph.D. at the University of Geneva, Switzerland. She has a Swiss Board Certification in Internal Medicine, specialty Oncology-Hematology. She also holds ABIM certifications in Internal Medicine and Medical Oncology. She has worked at Moffitt since 1994 and has been a Faculty Member since 1997. Her research focuses on cancer in the elderly. Her main areas of investigation are comorbidity, comprehensive assessment, and prediction/prevention of treatment toxicity in older cancer patients.


She is Past President of the International Society of Geriatric Oncology (SIOG), of which she is also a founding board member. She served or is serving on several ASCO committees and on the Editorial Board of the Journal of Clinical Oncology. Dr. Extermann was presented at ASCO 2009 with the B.J. Kennedy Award for Scientific Excellence in Geriatric Oncology. In October 2014, the International Society of Geriatric Oncology (SIOG) presented Dr. Extermann with the Paul Calabresi Award. On October 10, 2015, Dr. Extermann was presented with a Lifetime Achievement Award in Geriatric Oncology by the German Society of Geriatrics and German Society of Hematology/Oncology in Basel, Switzerland.

Policies and ethics