Overview
- Provides an up-to-date overview of TNF family signal transduction with a special emphasis on TRAIL and Fas L
- Deals with cell biology, immunology and oncology and in particular drug-resistance mechanisms, as well as prometastatic potential, related to the cell biology of the downstream signaling components of the TNF superfamily
- Addresses how post-translational modifications of TNF related members or their cleavage by proteases affect their signaling capacity
- Includes supplementary material: sn.pub/extras
Part of the book series: Resistance to Targeted Anti-Cancer Therapeutics (RTACT, volume 12)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (12 chapters)
Keywords
About this book
This volume provides the current understanding of death receptor's/TLR3 signaling regulation in cancer. Death receptors, including TRAIL-R1, TRAIL-R2, Fas and TNF-RI, owing to their ability to trigger apoptosis and to contribute to the elimination of cancer cells by the immune system have been considered, to variable extent, as important therapeutic targets for cancer therapy. But an increasing body of evidence suggests that some of these receptors may also contribute to tumorigenesis, or that new players such as TLR3 may be targeted for cancer therapy due to their ability to behave like death receptors.
Editors and Affiliations
About the editor
Bibliographic Information
Book Title: TRAIL, Fas Ligand, TNF and TLR3 in Cancer
Editors: Olivier Micheau
Series Title: Resistance to Targeted Anti-Cancer Therapeutics
DOI: https://doi.org/10.1007/978-3-319-56805-8
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing AG 2017
Hardcover ISBN: 978-3-319-56804-1Published: 10 July 2017
Softcover ISBN: 978-3-319-86006-0Published: 12 August 2018
eBook ISBN: 978-3-319-56805-8Published: 03 July 2017
Series ISSN: 2196-5501
Series E-ISSN: 2196-551X
Edition Number: 1
Number of Pages: XIII, 317
Number of Illustrations: 5 b/w illustrations, 35 illustrations in colour
Topics: Cancer Research