Molecular and Integrative Toxicology

Bone Toxicology

Editors: Smith, Susan Y., Varela, Aurore, Samadfam, Rana (Eds.)

  • Comparative bone biology of animal species commonly used in toxicology studies with humans 
  • Special considerations highlighted for Juvenile toxicology 
  • Collection of chapters on bone interactions with other organ systems
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  • ISBN 978-3-319-56192-9
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About this book

The content of this book is intended to provide the toxicologist in drug development in the pharmaceutical and biotechnology industries with a broad understanding of bone and its interactions with other organ systems in safety assessments.  The book is divided into three parts.  The first part describes our current understanding of bone biology and its primary regulatory pathways.  Additional chapters address regulatory and study design considerations for incorporating bone end points in toxicology studies, with special consideration being given to juvenile toxicology studies.  This is intended to address recent regulatory requirements to evaluate skeletal development for drugs in development for pediatric populations.  The second part of the book describes the principal techniques and methods used in bone research; understanding how these end-points are derived is fundamental to their appropriate application.  These first two parts of the book provide the background and the means to develop the concepts in part three which describes bone and its interaction with other organ systems.  The unique series of chapters in part three, contributed to by key leaders in their respective fields and in bone research, provides a comprehensive collective work.  Although constantly evolving, the crosstalk and interaction of the skeleton with several organ systems is now recognized and well documented, such as for the reproductive system, muscle and kidney, while our understanding of the interaction with other organ systems, such as the immune system and CNS, is in its infancy. Recent work highlights the key role of the skeleton in the regulation of energy metabolism and the impact this has on research in metabolic diseases such as obesity and diabetes. The hope is that this book will enlighten many and encourage more to explore the impact of new compounds on the skeleton in the development of effective and safe drugs.

About the authors

Susan Y. Smith is a consultant who specializes in nonclinical muscoloskeletal research. She provides guidance for the conduct of pharmacology, efficacy or safety studies, or help with data interpretation to unravel the mysteries of skeletal evaluations. She received a Master of Science in Pharmacology at McGill University and later joined Charles River Laboratories for almost 18 years and where she became Senior Scientific Director of Musculoskeletal Research. She has over 30 years of experience in preclinical safety assessments and toxicology and over 20 years of expertise in bone research.

Table of contents (15 chapters)

  • Introduction and Considerations in Bone Toxicology

    Smith, Susan Y. (et al.)

    Pages 3-26

  • Bone Physiology and Biology

    Gasser, Jürg Andreas (et al.)

    Pages 27-94

  • Specific Considerations for Bone Evaluations for Pediatric Therapeutics

    Robinson, Keith

    Pages 95-128

  • Animal Models in Bone Research

    Kimmel, Donald B.

    Pages 129-171

  • Biochemical Markers of Bone Turnover

    Smith, Susan Y. (et al.)

    Pages 175-201

Buy this book

eBook n/a
  • ISBN 978-3-319-56192-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
Hardcover n/a
  • ISBN 978-3-319-56190-5
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Bone Toxicology
Editors
  • Susan Y. Smith
  • Aurore Varela
  • Rana Samadfam
Series Title
Molecular and Integrative Toxicology
Copyright
2017
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG
eBook ISBN
978-3-319-56192-9
DOI
10.1007/978-3-319-56192-9
Hardcover ISBN
978-3-319-56190-5
Series ISSN
2168-4219
Edition Number
1
Number of Pages
XII, 474
Number of Illustrations and Tables
9 b/w illustrations, 63 illustrations in colour
Topics