Molecular Basis for Mitochondrial Signaling

1. Front Matter

   Pages i-xiv

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2. Mitochondrial Calcium Signaling

   1. Front Matter

      Pages 1-1

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   2. Mitochondrial Ca2+ Handling and Behind: The Importance of Being in Contact with Other Organelles

      • Riccardo Filadi, Pierre Theurey, Alice Rossi, Chiara Fedeli, Paola Pizzo

      Pages 3-39

   3. Molecular Players of Mitochondrial Calcium Signaling: Similarities and Different Aspects in Various Organisms

      • Vanessa Checchetto, Diego De Stefani, Anna Raffaello, Rosario Rizzuto, Ildiko Szabo

      Pages 41-65

3. The Mitochondrial Permeability Transition Pore: Structure and Function

   1. Front Matter

      Pages 67-67

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   2. The Mitochondrial Permeability Transition Pore: Molecular Structure and Function in Health and Disease

      • Elizabeth A. Jonas, George A. Porter Jr., Gisela Beutner, Nelli Mnatsakanyan, Han-A. Park, Nikita Mehta et al.

      Pages 69-105

   3. Mitochondrial Calcium Uptake in Activation of the Permeability Transition Pore and Cell Death

      • Maria E. Solesio, Evgeny V. Pavlov

      Pages 107-118

4. Mitochondrial Outer Membrane Transport Systems: Structure, Function, and Physiological Implications

   1. Front Matter

      Pages 119-119

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   2. Voltage-Dependent Anion Channels and Tubulin: Bioenergetic Controllers in Cancer Cells

      • Eduardo N. Maldonado, David N. DeHart, John J. Lemasters

      Pages 121-140

   3. An Assessment of How VDAC Structures Have Impacted Our Understanding of Their Function

      • Lucie Bergdoll, Michael Grabe, Jeff Abramson

      Pages 141-160

   4. Plant VDAC Permeability: Molecular Basis and Role in Oxidative Stress

      • Fabrice Homblé, Hana Kmita, Hayet Saidani, Marc Léonetti

      Pages 161-183

   5. Lipids in Regulation of the Mitochondrial Outer Membrane Permeability, Bioenergetics, and Metabolism

      • Tatiana K. Rostovtseva, David P. Hoogerheide, Amandine Rovini, Sergey M. Bezrukov

      Pages 185-215

   6. The Mitochondrial Outer Membrane Potential as an Electrical Feedback Control of Cell Energy Metabolism

      • Victor V. Lemeshko

      Pages 217-250

5. Mitochondria and Cellular Signaling Network

   1. Front Matter

      Pages 251-251

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   2. New Insights on the Regulation of Programmed Cell Death by Bcl-2 Family Proteins at the Mitochondria: Physiological and Pathophysiological Implications

      • Laurent Dejean, Stéphen Manon

      Pages 253-283

   3. The 18 kDa Translocator Protein (TSPO): Cholesterol Trafficking and the Biology of a Prognostic and Therapeutic Mitochondrial Target

      • Michele Frison, Anna Katherina Mallach, Emma Kennedy, Michelangelo Campanella

      Pages 285-315

   4. Protein Import Channels in the Crossroads of Mitochondrial Function

      • Ma Su Su Aung, Ruth Hartke, Stephen Madamba, Oygul Mirzalieva, Pablo M. Peixoto

      Pages 317-347

   5. Substrate Selection and Its Impact on Mitochondrial Respiration and Redox

      • Sonia Cortassa, Steven J. Sollott, Miguel A. Aon

      Pages 349-375

6. Back Matter

   Pages 377-386

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This book covers recent advances in the study of structure, function, and regulation of metabolite, protein and ion translocating channels, and transporters in mitochondria. A wide array of cutting-edge methods are covered, ranging from electrophysiology and cell biology to bioinformatics, as well as structural, systems, and computational biology. At last, the molecular identity of two important channels in the mitochondrial inner membrane, the mitochondrial calcium uniporter and the mitochondrial permeability transition pore have been established. After years of work on the physiology and structure of VDAC channels in the mitochondrial outer membrane, there have been multiple discoveries on VDAC permeation and regulation by cytosolic proteins. Recent breakthroughs in structural studies of the mitochondrial cholesterol translocator reveal a set of novel unexpected features and provide essential clues for defining therapeutic strategies. Molecular Basis for Mitochondrial Signaling covers these and many more recent studies of mitochondria function, their communication with other organelles, and their critical roles in development, aging, and in a plethora of stressful or degenerative events. Authored by leading researchers in the field, this volume will be an indispensable reference resource for graduate students and academics working in related areas of biophysics and cell biology as well as for professionals within industry.

• Biophysics of membrane transport
• Calcium signaling
• Cellular metabolism
• Ion channels and transporters
• Mitochondria and disease
• Mitochondria in apoptosis
• Mitochondrial metabolism
• Proapoptotic proteins
• Cell Cycle Analysis
• Apoptosis

• Section on Molecular Transport, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, USA

  Tatiana K. Rostovtseva

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