Biological and Medical Physics, Biomedical Engineering

Molecular Basis for Mitochondrial Signaling

Editors: Rostovtseva, Tatiana K (Ed.)

  • Covers advanced studies of structure, function, and regulation of the unique family of mitochondrial channels and transporters
  • Describes the current understanding of the mitochondria‚Äôs role in cellular signaling in health and disease
  • Features structural and functional studies of membrane proteins in mitochondria
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eBook $149.00
price for USA (gross)
  • ISBN 978-3-319-55539-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-3-319-55537-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book covers recent advances in the study of structure, function, and regulation of metabolite, protein and ion translocating channels, and transporters in mitochondria. A wide array of cutting-edge methods are covered, ranging from electrophysiology and cell biology to bioinformatics, as well as structural, systems, and computational biology. At last, the molecular identity of two important channels in the mitochondrial inner membrane, the mitochondrial calcium uniporter and the mitochondrial permeability transition pore have been established. After years of work on the physiology and structure of VDAC channels in the mitochondrial outer membrane, there have been multiple discoveries on VDAC permeation and regulation by cytosolic proteins. Recent breakthroughs in structural studies of the mitochondrial cholesterol translocator reveal a set of novel unexpected features and provide essential clues for defining therapeutic strategies. Molecular Basis for Mitochondrial Signaling covers these and many more recent studies of mitochondria function, their communication with other organelles, and their critical roles in development, aging, and in a plethora of stressful or degenerative events. Authored by leading researchers in the field, this volume will be an indispensable reference resource for graduate students and academics working in related areas of biophysics and cell biology as well as for professionals within industry.

Table of contents (13 chapters)

  • Mitochondrial Ca2+ Handling and Behind: The Importance of Being in Contact with Other Organelles

    Filadi, Riccardo (et al.)

    Pages 3-39

  • Molecular Players of Mitochondrial Calcium Signaling: Similarities and Different Aspects in Various Organisms

    Checchetto, Vanessa (et al.)

    Pages 41-65

  • The Mitochondrial Permeability Transition Pore: Molecular Structure and Function in Health and Disease

    Jonas, Elizabeth A. (et al.)

    Pages 69-105

  • Mitochondrial Calcium Uptake in Activation of the Permeability Transition Pore and Cell Death

    Solesio, Maria E. (et al.)

    Pages 107-118

  • Voltage-Dependent Anion Channels and Tubulin: Bioenergetic Controllers in Cancer Cells

    Maldonado, Eduardo N. (et al.)

    Pages 121-140

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-3-319-55539-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-3-319-55537-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Molecular Basis for Mitochondrial Signaling
Editors
  • Tatiana K Rostovtseva
Series Title
Biological and Medical Physics, Biomedical Engineering
Copyright
2017
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG
eBook ISBN
978-3-319-55539-3
DOI
10.1007/978-3-319-55539-3
Hardcover ISBN
978-3-319-55537-9
Series ISSN
1618-7210
Edition Number
1
Number of Pages
XIV, 386
Number of Illustrations and Tables
7 b/w illustrations, 54 illustrations in colour
Topics