Editors:
- Provide current state of research on metals in human biology, health and disease
- A state of the art molecular details delineating the metal related cancers with synthesis and analyses of the available facts for the mode of action predictions in cancer burden
- A critical review on current research affairs to gain fundamental understanding on the biological mechanisms involved in health and effects of metals-induced cancers including genetic, epigenetic aspects on the disease etiology, progress or outcome
Part of the book series: Molecular and Integrative Toxicology (MOLECUL)
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Table of contents (9 chapters)
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Front Matter
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Back Matter
About this book
This book aims to present current state of understanding of the role of metals in human health and disease. As it will be difficult to cover all of the metals, about two scores of them, the authors will instead provide a detailed analysis of a select set of essential (Calcium, Magnesium, Selenium, Iron, copper and Zinc) and non-essential metals (Nickel, Chromium, Cadmium and Arsenic, Tungsten and Asbestos). Each chapter will have a dedicated section focusing on the binary role that some of these metals play, their carcinogenic and cancer therapeutics, by integrating epidemiological, experimental evidence with special emphasis and focus on molecular mechanisms involved in these processes. The biological analysis will also include emerging lines of evidence such as micro RNAS, kinase families, receptors, endoplasmic, mitochondrial players and epigenetics. As part of integrating the human, experimental and mechanistic data, as well as a detailed analysis into the modes of actionfor different cancer outcomes will be discussed in each chapter wherever deemed feasible. These approaches are ones in which no other book in this area has attempted to do.
Editors and Affiliations
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Natl Ctr Envtl Assessment Office of Res and Devt, Research Triangle Park, USA
Anuradha Mudipalli
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Professor of Environmental Medicine, New York University, Tuxedo, USA
Judith T. Zelikoff
About the editors
Anu Mudipalli is a Senior Biologist, working for the US Environmental Protection agency, USA. Dr. Mudipalli obtained a Ph.D. in Human Nutrition and Biochemistry for her joint work with ‘Sri Venkateswara University’ and ‘Indian Institute of Chemical Toxicology’, India. She joined Roswell Park Cancer Institute, Buffalo, NY in the department of ‘Experimental Therapeutics’, where she was a postdoctoral fellow and research associate and obtained her training in Chemical carcinogenesis and chemotherapeutics.
Her work in EPA for the past 15 years focuses on carcinogenic mechanisms of chemical carcinogens and human health risk assessment of various chemical entities for hazard identification, mode of action and quantitative risk assessment. For the past several years, she has been a standing member for EPA’s internal review committees on ‘Superfund’ and ‘Integrated Risk information system’ documents for human health risk assessment. Besides, she served as EPA’s expert review panel member for documents from international organizations such as UNEP(Lead and Cadmium) and OECD.
Dr. Mudipalli has authored for reputed scientific journals, edited a special edition on metals for Indian Journal of Medical Research, serves as an expert peer reviewer for more than a dozen reputed international scientific journals and presented in several National and international meetings. She is the recipient of EPA’s prestigious awards such as a bronze medal and a level 1 Scientific and technological award (STAA).
Bibliographic Information
Book Title: Essential and Non-essential Metals
Book Subtitle: Carcinogenesis, Prevention and Cancer Therapeutics
Editors: Anuradha Mudipalli, Judith T. Zelikoff
Series Title: Molecular and Integrative Toxicology
DOI: https://doi.org/10.1007/978-3-319-55448-8
Publisher: Humana Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2017
Hardcover ISBN: 978-3-319-55446-4Published: 26 July 2017
Softcover ISBN: 978-3-319-85664-3Published: 12 August 2018
eBook ISBN: 978-3-319-55448-8Published: 14 July 2017
Series ISSN: 2168-4219
Series E-ISSN: 2168-4235
Edition Number: 1
Number of Pages: XII, 228
Number of Illustrations: 9 b/w illustrations, 65 illustrations in colour
Topics: Cancer Research, Molecular Medicine