Cardiac and Vascular Biology

Microdomains in the Cardiovascular System

Editors: Nikolaev, Viacheslav, Zaccolo, Manuela (Eds.)

  • First book comprehensively reviewing signaling microdomains in the cardiovascular system
  • Thoroughly explains important cellular events and mechanisms
  • Highlights the role of microdomains in cardiovascular disease 
  • Experts provide insight into successful methodologies and techniques
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Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-3-319-54579-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-3-319-54578-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The book comprehensively presents new findings in cardiovascular research related to signaling microdomains in health and disease. Important second messengers such as cAMP, cGMP, calcium and their role in microdomain signaling are discussed. The book offers and explains methodical approaches and technical ways how to successfully analyze microdomain signaling, also in the context of disease. It further provides scientific perspectives and strategies that are based on the concept of signaling within microdomains and that can revolutionize pharmacology and eventually lead to the effective treatment of cardiovascular diseases in future.This book is written for scientists in cardiovascular research, pharmacology, molecular and cellular biology as well as medical doctors in cardiology, angiology and nephrology. 

About the authors

Prof. Viacheslav Nikolaev, PhD is the Director of the Institute of Experimental Cardiovascular Research at the University Medical Center Hamburg-Eppendorf, Germany. He is also a member of the German Center for Cardiovascular Research (DZHK). His main interest is live-cell imaging of cardiac cAMP and cGMP microdomains and their role in heart failure.

 

Prof. Manuela Zaccolo, MD is the Director of the Burdon Sanderson Cardiac Science Centre and works in the Department of Physiology, Anatomy and Genetics at the University of Oxford. She is interested in the regulatory principles by which intracellular signalling networks achieve the plasticity and context-sensitivity necessary for a cell to function. A central topic of her research is the role of local regulation of cyclic nucleotide signalling in healthy and diseased hearts.   

Table of contents (17 chapters)

  • Receptor-Cyclic Nucleotide Microdomains in the Heart

    Bork, Nadja I. (et al.)

    Pages 3-15

  • Membrane Microdomains and cAMP Compartmentation in Cardiac Myocytes

    Agarwal, Shailesh R. (et al.)

    Pages 17-35

  • Function to Failure: Compartmentalization of Cardiomyocyte Signaling by A-Kinase-Anchoring Proteins

    Redden, John M. (et al.)

    Pages 37-57

  • Pharmacological Approaches for Delineating Functions of AKAP-Based Signalling Complexes and Finding Therapeutic Targets

    Schrade, Katharina (et al.)

    Pages 59-83

  • Chatting Second Messengers: PIP3 and cAMP

    Ghigo, Alessandra (et al.)

    Pages 85-95

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-3-319-54579-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-3-319-54578-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Microdomains in the Cardiovascular System
Editors
  • Viacheslav Nikolaev
  • Manuela Zaccolo
Series Title
Cardiac and Vascular Biology
Copyright
2017
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG
eBook ISBN
978-3-319-54579-0
DOI
10.1007/978-3-319-54579-0
Hardcover ISBN
978-3-319-54578-3
Series ISSN
2509-7830
Edition Number
1
Number of Pages
VIII, 386
Number of Illustrations and Tables
2 b/w illustrations, 32 illustrations in colour
Topics