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Translational Anatomy and Cell Biology of Autism Spectrum Disorder

  • Book
  • © 2017

Overview

Editors:
  1. Michael J. Schmeisser

    1. Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Tobias M. Boeckers

    1. Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Broadens your understanding of Autism Spectrum disorder
  • Reviews exhaustively the key recent research into animal models of ASD
  • Includes research on modeling autistic neurons with induced pluripotent stem cells

Part of the book series: Advances in Anatomy, Embryology and Cell Biology (ADVSANAT, volume 224)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Anatomy and Cell Biology of Autism Spectrum Disorder: Lessons from Human Genetics

    • Kristel T. E. Kleijer, Guillaume Huguet, Julie Tastet, Thomas Bourgeron, J. P. H. Burbach
    Pages 1-25

  3. Neuroanatomy and Neuropathology of Autism Spectrum Disorder in Humans

    • Christine Ecker, Michael J. Schmeisser, Eva Loth, Declan G. Murphy
    Pages 27-48

  4. Modelling Autistic Neurons with Induced Pluripotent Stem Cells

    • Annie Kathuria, Carlo Sala, Chiara Verpelli, Jack Price
    Pages 49-64

  5. Modelling Autistic Features in Mice Using Quantitative Genetic Approaches

    • Remco T. Molenhuis, Hilgo Bruining, Martien J. Kas
    Pages 65-84

  6. Behavioural Phenotypes and Neural Circuit Dysfunctions in Mouse Models of Autism Spectrum Disorder

    • Allain-Thibeault Ferhat, Sonja Halbedl, Michael J. Schmeisser, Martien J. Kas, Thomas Bourgeron, Elodie Ey
    Pages 85-101

  7. Cerebellar and Striatal Pathologies in Mouse Models of Autism Spectrum Disorder

    • SaÅ¡a Peter, Chris I. De Zeeuw, Tobias M. Boeckers, Michael J. Schmeisser
    Pages 103-119

  8. Neurotrophic Factors in Mouse Models of Autism Spectrum Disorder: Focus on BDNF and IGF-1

    • Dominik Reim, Michael J. Schmeisser
    Pages 121-134

  9. The Role of the Oxytocin/Arginine Vasopressin System in Animal Models of Autism Spectrum Disorder

    • Rong Zhang, Xin-Jie Xu, Hong-Feng Zhang, Song-Ping Han, Ji-Sheng Han
    Pages 135-158

  10. Extracerebral Dysfunction in Animal Models of Autism Spectrum Disorder

    • Elisa L. Hill-Yardin, Sonja J. McKeown, Gaia Novarino, Andreas M. Grabrucker
    Pages 159-187

  11. Genetic and Pharmacological Reversibility of Phenotypes in Mouse Models of Autism Spectrum Disorder

    • Jan C. Schroeder, Elena Deliu, Gaia Novarino, Michael J. Schmeisser
    Pages 189-211
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Keywords

About this book

Autism spectrum disorder (ASD) affects approximately 1 % of the human population and is characterized by a core symptomatology including deficits in social interaction and repetitive patterns of behaviour plus various co-morbidities. Although a lot of progress has been made to uncover underlying causes and mechanisms throughout the last decade, we are still at the very beginning to understand this enormously complex neurodevelopmental condition. This special volume is focused on translational anatomy and cell biology of ASD. International experts from the field including several members of the EU-AIMS initiative launched by the European Union to develop novel treatments for ASD have contributed chapters on several topics covering all crucial aspects of translational ASD research with a special emphasis on ASD model systems including stem cells and animals. Primary objective is to clarify how anatomical and cell biological phenotypes of ASD will help to translate basic mechanisms to clinical practice and to efficiently treat affected individuals in the near future.

Editors and Affiliations

  • Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany

    Michael J. Schmeisser, Tobias M. Boeckers

About the editors

Prof. Michael J. Schmeisser, MD PhD

 Michael Schmeisser was born in 1983, went to medical school in Ulm, Boston, Glasgow and Basel and obtained both his MD and PhD degrees from Ulm University. He further specialized in anatomy and molecular neuroscience and was appointed full professor of Neuroanatomy at the Otto-von-Guericke University Magdeburg in 2017. Prof. Schmeisser’s translational research is related to molecular pathomechanisms of neuropsychiatric disorders. He is especially interested in understanding the impact of rare genetic disorders affecting the developing nervous system and the molecular interrelation between autism and intellectual disability.

 

Prof. Tobias M. Boeckers, MD

 Tobias Boeckers was born in 1964, went to medical school in Münster, Wellington and Seattle and obtained his MD degree from Münster University. He further specialized in anatomy and molecular neurobiology and was appointed full professor and director of the Institute for Anatomy and Cell Biology at Ulm University in 2003. During his postdoctoral time at the Leibniz Institute for Neurobiology in Madgeburg in the 90s, he discovered the SHANKs, a family of synaptic scaffolding proteins whose genetic disruptions later became most relevant for the pathogenesis of autism spectrum disorder.  Prof. Boeckers has a broad research focus on basic and translational neuroscience that includes the role of SHANK in both health and disease, molecular pathomechanisms of neurodegenerative disorders and the neurobiology of trauma.

 

Bibliographic Information

  • Book Title: Translational Anatomy and Cell Biology of Autism Spectrum Disorder

  • Editors: Michael J. Schmeisser, Tobias M. Boeckers

  • Series Title: Advances in Anatomy, Embryology and Cell Biology

  • DOI: https://doi.org/10.1007/978-3-319-52498-6

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2017

  • Softcover ISBN: 978-3-319-52496-2Published: 07 June 2017

  • eBook ISBN: 978-3-319-52498-6Published: 25 May 2017

  • Series ISSN: 0301-5556

  • Series E-ISSN: 2192-7065

  • Edition Number: 1

  • Number of Pages: VIII, 211

  • Number of Illustrations: 17 illustrations in colour

  • Topics: Neurosciences, Psychiatry, Cell Biology

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