Editors:
- Drs. Schwartz and Lanza are two of the best known names in stem cell research and Dr. Schwartz is known particularly for clinical trials for stem cell therapies for ophthalmologic diseases
- Focuses on strategies for developing and transplanting cells rather than taking a disease-centric approach
- Contains chapters that review parallel other approaches not involving cellular transplantation
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Table of contents (11 chapters)
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Front Matter
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Cell Replacement Therapy
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Front Matter
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Cell-based Neuroprotection
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Front Matter
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Disease Modeling Using Induced Pluripotent Stem Cells
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Front Matter
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Back Matter
About this book
The use of cellular transplantation to treat retinal disease has recently become a viable and exciting therapeutic approach. The visibility of the retina and its laminar cellular architecture render it an ideal organ for the development of surgically delivered cellular therapies. Having an in-depth understanding ofthe current state of cell therapy for the eye is an essential first step toward utilizing similar approaches in other organs. Ophthalmologists, translational clinician-scientists, stem cell scientists, and researchers interested in eye disease will find Cellular Therapies for Retinal Disease: A Strategic Approach essential reading and it is also suitable for workshops or courses at the undergraduate or Ph.D. level.
Editors and Affiliations
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Retina Division Chief; Department of Ophthalmology; Ahmanson Professor of Ophthalmology, Stein Eye Institute; David Geffen School of Medicine at UCLA, Los Angeles, USA
Steven D. Schwartz
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Retina Division; Department of Ophthalmology, Stein Eye Institute; David Geffen School of Medicine at UCLA, Los Angeles, USA
Aaron Nagiel
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Head of Astellas Global Regenerative Medicine, Chief Scientific Officer at the Astellas Institute for Regenerative Medicine, Marlborough, USA
Robert Lanza
About the editors
Steven Schwartz, M.D., Ahmanson Professor of Ophthalmology, the Stein Eye Institute at UCLA, is a recognized expert in translational research with a successful track record including contributions to anti-vascular endothelial growth factor therapeutics, drug delivery systems, vitreoretinal diagnostic imaging instrumentation, novel therapeutic lasers and surgical devices including a novel microsurgical robotic system. Currently he is leading the first clinical trials of human embryonic stem cell derived RPE transplanted into patients with Age Related Macular Degeneration and Stargardt macular degeneration. His research is widely published with over 100 peer-reviewed publications including the lead article on the first in human successful stem cell therapy in the Lancet. He has received numerous awards for scientific, clinical and humanitarian contributions including the American Academy of Ophthalmology’s Secretariat Award.
Aaron Nagiel, MD, PhD is a second-year vitreoretinal fellow at the Stein Eye Institute at UCLA. After graduating from Harvard College, he received MD and PhD degrees at Cornell University and The Rockefeller University in New York City. He completed ophthalmology residency training at Stein and is a recipient of the Heed Ophthalmic Foundation Fellowship and the Ronald G. Michels Foundation Fellowship. He has contributed to several publications on retinal imaging and cell-based therapies for retinal disease.
Robert Lanza, M.D. is currently Head of Astellas Global Regenerative Medicine, and is Chief Scientific Officer of the Astellas Institute for Regenerative Medicine and Adjunct Professor at Wake Forest University School of Medicine. He has several hundred publications and inventions, and over 30 scientific books: among them, “Essentials of Stem Cell Biology” and “Principles of Tissue Engineering” which are recognized as the definitive references in the field. He is a former Fulbright Scholar, and studied as a student with polio-pioneer Jonas Salk and Nobel laureates Gerald Edelman and Rodney Porter. He also worked closely (and co-authored a series of papers) with noted Harvard psychologist B.F. Skinner and heart transplant pioneer Christiaan Barnard. Dr. Lanza received his undergraduate and medical degrees from the University of Pennsylvania, where he was both a University Scholar and Benjamin Franklin Scholar. In 2014, Time magazine recognized him as one of the “100 Most Influential People in the World,” and in 2015, Prospect magazine named him one of the Top 50 “World Thinkers.”
Bibliographic Information
Book Title: Cellular Therapies for Retinal Disease
Book Subtitle: A Strategic Approach
Editors: Steven D. Schwartz, Aaron Nagiel, Robert Lanza
DOI: https://doi.org/10.1007/978-3-319-49479-1
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing AG 2017
Hardcover ISBN: 978-3-319-49477-7Published: 06 July 2017
Softcover ISBN: 978-3-319-84169-4Published: 12 May 2018
eBook ISBN: 978-3-319-49479-1Published: 20 June 2017
Edition Number: 1
Number of Pages: XIII, 143
Number of Illustrations: 5 b/w illustrations, 38 illustrations in colour
Topics: Stem Cells, Ophthalmology