Obesity and Lipotoxicity

1. Front Matter

   Pages i-viii

   PDF

2. The Definition and Prevalence of Obesity and Metabolic Syndrome

   • Atilla Engin

   Pages 1-17

3. Circadian Rhythms in Diet-Induced Obesity

   • Atilla Engin

   Pages 19-52

4. Eat and Death: Chronic Over-Eating

   • Atilla Engin

   Pages 53-80

5. Obesity, Persistent Organic Pollutants and Related Health Problems

   • Loukia Vassilopoulou, Christos Psycharakis, Demetrios Petrakis, John Tsiaoussis, Aristides M. Tsatsakis

   Pages 81-110

6. Human Protein Kinases and Obesity

   • Atilla Engin

   Pages 111-134

7. Fat Cell and Fatty Acid Turnover in Obesity

   • Atilla Engin

   Pages 135-160

8. Adipose Tissue Function and Expandability as Determinants of Lipotoxicity and the Metabolic Syndrome

   • Stefania Carobbio, Vanessa Pellegrinelli, Antonio Vidal-Puig

   Pages 161-196

9. What Is Lipotoxicity?

   • Ayse Basak Engin

   Pages 197-220

10. The Pathogenesis of Obesity-Associated Adipose Tissue Inflammation

    • Atilla Engin

    Pages 221-245

11. Microbiota and Lipotoxicity

    • Evren Doruk Engin

    Pages 247-260

12. Endoplasmic Reticulum Stress and Obesity

    • Erkan Yilmaz

    Pages 261-276

13. Insulin Resistance, Obesity and Lipotoxicity

    • Dilek Yazıcı, Havva Sezer

    Pages 277-304

14. Adipose Tissue Hypoxia in Obesity and Its Impact on Preadipocytes and Macrophages: Hypoxia Hypothesis

    • Atilla Engin

    Pages 305-326

15. Adipocyte-Macrophage Cross-Talk in Obesity

    • Ayse Basak Engin

    Pages 327-343

16. Endothelial Dysfunction in Obesity

    • Atilla Engin

    Pages 345-379

17. Diet-Induced Obesity and the Mechanism of Leptin Resistance

    • Atilla Engin

    Pages 381-397

18. Influence of Antioxidants on Leptin Metabolism and its Role in the Pathogenesis of Obesity

    • Harald Mangge, Christian Ciardi, Kathrin Becker, Barbara Strasser, Dietmar Fuchs, Johanna M. Gostner

    Pages 399-413

19. Adiponectin-Resistance in Obesity

    • Atilla Engin

    Pages 415-441

20. Non-Alcoholic Fatty Liver Disease

    • Atilla Engin

    Pages 443-467

Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. “Obesity and Lipotoxicity” is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin, adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. “Lipotoxicity and Obesity” will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field.

• Adipose Tissue Hypoxia
• Lipolysis
• Lipotoxicity
• Obesity
• Protein Kinases

“The aim is to discuss the many critical and complex topics that trigger obesity with the hope that the book will encourage and further the research of scientists and practitioners who are interested in obesity. … This book is intended as a useful resource for clinicians and basic science researchers such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, and cardiologists, as well as students who are interested in this field.” (L. Anne Gilmore, Doody's Book Reviews, September, 2017)

• Faculty of Pharmacy, Department of Toxicology, Gazi University, Hipodrom, Turkey

  Ayse Basak Engin

• Faculty of Medicine, Department of General Surgery, Gazi University, Besevler, Turkey

  Atilla Engin

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