More than 1,900 Springer Protocols eBooks at just $9.99 each! Get yours today>>

Human Retrotransposons in Health and Disease

Editors: Cristofari, Gael (Ed.)

  • Authored by leading experts in the field
  • The first book to explore not only insertion-based effects and their related consequences on germline and somatic genome dynamics, but also the role and impact of retrotransposons sequences in it's broader context
  • Includes sections on lncRNA, neuronal disorders, and exaptation
see more benefits

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-3-319-48344-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-3-319-48343-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This unique book explores the role of retrotransposons in human health and disease. The ability of retrotransposons to affect the structure of human genes is recognized since the late 80’s. However, the advances of deep-sequencing technologies have shed new light on the extent of retrotransposon-mediated genome variations. These progresses have also led to the discovery that retrotransposon activity is not restricted to the germline - resulting in inheritable genetic variations - but can also mobilize in somatic tissues, such as embryonic stem cells, neuronal progenitor cells, or in many cancers. This book covers topics related to the effects of retrotransposon insertions, and their consequences on germline and somatic genome dynamics, but also discuss the role and impact of retrotransposons sequences in a broader context, including a number of novel topics that emerged recently (long non-coding RNA, neuronal disorders, exaptation) with unexpected connections between retrotransposons, stem cell maintenance, placentation, circadian cycles or aging.

About the authors

Gael Cristofari is a biomedical expert in Molecular Biology & Genetics and Biology & Biochemistry at IRCAN, in Nice, France.

Table of contents (13 chapters)

  • Retrotransposons and the Mammalian Germline

    Adams, Ian R.

    Pages 1-28

  • L1 Regulation in Mouse and Human Germ Cells

    Newkirk, Simon J. (et al.)

    Pages 29-61

  • Retrotransposon Contribution to Genomic Plasticity

    Doucet-O’Hare, Tara T. (et al.)

    Pages 63-93

  • The Mobilisation of Processed Transcripts in Germline and Somatic Tissues

    Ewing, Adam D.

    Pages 95-106

  • Neuronal Genome Plasticity: Retrotransposons, Environment and Disease

    Kempen, Marie-Jeanne H. C. (et al.)

    Pages 107-125

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-3-319-48344-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-3-319-48343-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Human Retrotransposons in Health and Disease
Editors
  • Gael Cristofari
Copyright
2017
Publisher
Springer International Publishing
Copyright Holder
The Editor(s) (if applicable) and The Author(s) 2018
eBook ISBN
978-3-319-48344-3
DOI
10.1007/978-3-319-48344-3
Hardcover ISBN
978-3-319-48343-6
Edition Number
1
Number of Pages
X, 330
Number of Illustrations and Tables
6 b/w illustrations, 28 illustrations in colour
Topics