Milestones in Drug Therapy

Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins

Editors: Grawunder, Ulf, Barth, Stefan (Eds.)

  • Offers cutting-edge information on the development of antibody drug conjugates and recombinant immunotoxins
  • Explores related basic biological and chemical technologies and promotes new developments toward clinical applications
  • Primarily aimed at postgraduate students, researchers and clinicians
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eBook $129.00
price for USA (gross)
  • ISBN 978-3-319-46877-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.00
price for USA
  • ISBN 978-3-319-46875-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities.

The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology.


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Table of contents (8 chapters)

  • Chemical Assembly of Antibody-Drug Conjugates

    Nanna, Alex R. (et al.)

    Pages 1-28

  • Preclinical Evaluation of ADCs Delivering Highly Potent Pyrrolobenzodiazepine (PBD) Dimers

    Hartley, John A.

    Pages 29-46

  • Stable and Homogeneous Drug Conjugation by Sequential Bis-Alkylation at Disulphide Bonds Using Bis-Sulphone Reagents

    Pabst, Martin (et al.)

    Pages 47-67

  • Calicheamicin Antibody-Drug Conjugates for Liquid and Solid Tumor Indications

    Gerber, Hans-Peter (et al.)

    Pages 69-84

  • Enzyme-Based Strategies to Generate Site-Specifically Conjugated Antibody Drug Conjugates

    Beerli, Roger R. (et al.)

    Pages 85-106

Buy this book

eBook $129.00
price for USA (gross)
  • ISBN 978-3-319-46877-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.00
price for USA
  • ISBN 978-3-319-46875-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins
Editors
  • Ulf Grawunder
  • Stefan Barth
Series Title
Milestones in Drug Therapy
Copyright
2017
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG
eBook ISBN
978-3-319-46877-8
DOI
10.1007/978-3-319-46877-8
Hardcover ISBN
978-3-319-46875-4
Series ISSN
2296-6056
Edition Number
1
Number of Pages
XI, 181
Number of Illustrations and Tables
18 b/w illustrations, 39 illustrations in colour
Topics