Antimicrobial Drug Resistance

Mechanisms of Drug Resistance, Volume 1

Editors: Mayers, D.L., Sobel, J.D., Ouellette, M., Kaye, K.S., Marchaim, D. (Eds.)

  • New chapters and authors on recent developments in drug resistance
  • Expertise from over 197 international professionals in the field
  • Discusses drug resistance genes and the implementation of genomic data
  • Additional three new topics regarding increasingly important public health issues
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eBook $309.00
price for USA (gross)
  • ISBN 978-3-319-46718-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $399.00
price for USA
  • ISBN 978-3-319-46716-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The two volumes included in Antimicrobial Drug Resistance, Second Edition is an updated, comprehensive and multidisciplinary reference covering the area of antimicrobial drug resistance in bacteria, fungi, viruses, and parasites from basic science, clinical, and epidemiological perspectives. This newly revised compendium reviews the most current research and development on drug resistance while still providing the information in the accessible format of the first edition. The first volume, Antimicrobial Drug Resistance: Mechanisms of Drug Resistance, is dedicated to the biological basis of drug resistance and effective avenues for drug development. With the emergence of more drug-resistant organisms, the approach to dealing with the drug resistance problem must include the research of different aspects of the mechanisms of bacterial resistance and the dissemination of resistance genes as well as research utilizing new genomic information. These approaches will permit the design of novel strategies to develop new antibiotics and preserve the effectiveness of those currently available. The second volume, Antimicrobial Drug Resistance: Clinical and Epidemiological Aspects, is devoted to the clinical aspects of drug resistance. Although there is evidence that restricted use of a specific antibiotic can be followed by a decrease in drug resistance to that agent, drug resistance control is not easily achieved. Thus, the infectious diseases physician requires input from the clinical microbiologist, antimicrobial stewardship personnel, and infection control specialist to make informed choices for the effective management of various strains of drug-resistant pathogens in individual patients. This 2-volume set is an important reference for students in microbiology, infectious diseases physicians, medical students, basic scientists, drug development researchers, microbiologists, epidemiologists, and public health practitioners.

About the authors

Douglas L. Mayers is an infectious diseases specialist and is currently Chief Medical Officer (CMO) at Cocrystal Pharma. Dr. Mayers received his M.D. from University of Pennsylvania and has over 20 years of medical and clinical development experience spanning all phases of global clinical research and development and commercialization. He has worked with the United States Army Medical Research Institute of Infectious Diseases to discover and develop drugs against the Ebola virus. He has also served as the Head of HIV Clinical Studies Program and Department of HIV Disease Prevention at the Walter Reed Army Institute of Research and Naval Medical Research Institute. Previously, he was the Chief Medical Officer and Executive Vice President at Idenix Pharmaceuticals, where he directed the Infectious Disease programs and led numerous regulatory filings globally, including successful advancement of several anti-HCV candidates to the clinical phase. Prior to Idenix, he was the International Head/Vice President of the Virology Therapeutic Area at Boehringer Ingelheim where he led Phase 1 through 4 clinical studies for HIV and hepatitis programs. In addition to his extensive expertise in the industry and in research, Dr. Mayers is well-known in the academic sphere and is the author of over 95 peer-reviewed publications and book chapters.

Table of contents (48 chapters)

  • History of Drug-Resistant Microbes

    Jacoby, George A.

    Pages 3-8

  • Evolutionary Biology of Drug Resistance

    Baquero, Fernando (et al.)

    Pages 9-36

  • Pharmacology of Drug Resistance

    Andrews, Elizabeth R. (et al.)

    Pages 37-43

  • Drug Development for Drug-Resistant Pathogens

    Dumas, Jacques (et al.)

    Pages 45-57

  • Genetic Mechanisms of Transfer of Drug Resistance

    Roy, Paul H. (et al.)

    Pages 61-76

Buy this book

eBook $309.00
price for USA (gross)
  • ISBN 978-3-319-46718-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $399.00
price for USA
  • ISBN 978-3-319-46716-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Antimicrobial Drug Resistance
Book Subtitle
Mechanisms of Drug Resistance, Volume 1
Editors
  • Douglas L. Mayers
  • Jack D. Sobel
  • Marc Ouellette
  • Keith S. Kaye
  • Dror Marchaim
Copyright
2017
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG
eBook ISBN
978-3-319-46718-4
DOI
10.1007/978-3-319-46718-4
Hardcover ISBN
978-3-319-46716-0
Edition Number
2
Number of Pages
XXI, 773
Number of Illustrations and Tables
103 b/w illustrations, 61 illustrations in colour
Topics