Clinical Guide to Heart Transplantation

1. Front Matter

   Pages i-xii

   PDF

2. Medical and Device Options for Patients with End-Stage Heart Failure

   • Michele Hamilton, Michelle Kittleson, Jon Kobashigawa

   Pages 1-9

3. Mechanical and Surgical Options for Patients with End-Stage Heart Failure

   • Jaime Moriguchi

   Pages 11-19

4. Evaluation for Heart Transplant Candidacy

   • Jon Kobashigawa, Minh Luu, Christine Sumbi

   Pages 21-35

5. Listing, Donor Allocation and Optimization of the Pre-transplant Patient

   • Michelle Kittleson, Jon Kobashigawa, Minh Luu

   Pages 37-45

6. Overview of Transplantation Immunobiology

   • Xiaohai Zhang, Nancy Reinsmoen, Jon Kobashigawa

   Pages 47-56

7. The Sensitized Patient Awaiting Heart Transplantation

   • Jignesh Patel, Jon Kobashigawa

   Pages 57-71

8. Donor Organ Preservation and Surgical Considerations in Heart Transplantation

   • Fardad Esmailian, Paul Perry, Jon Kobashigawa

   Pages 73-80

9. Physiology of the Transplanted Heart

   • Jon Kobashigawa, Michael Olymbios

   Pages 81-93

10. Immediate Post-operative Management After Heart Transplantation

    • Jon Kobashigawa, Minh Luu

    Pages 95-108

11. Immunosuppression Strategies in Heart Transplantation

    • Jon Kobashigawa, Minh Luu

    Pages 109-135

12. Managing Infections in Cardiac Transplantation

    • Phillip Zakowski

    Pages 137-156

13. Cardiac Allograft Rejection, Surveillance and Treatment

    • David Chang, Jon Kobashigawa

    Pages 157-170

14. Outpatient Management and Long-Term Complications in Heart Transplantation

    • David Chang, Jon Kobashigawa, Minh Luu

    Pages 171-183

15. Quality of Life After Heart Transplantation

    • Jon Kobashigawa, Michael Olymbios

    Pages 185-191

16. Pediatric Heart Transplantation: Special Considerations

    • Jon Kobashigawa, Michael Olymbios

    Pages 193-211

17. Combined Heart and Other Organ Transplant

    • Jon Kobashigawa, Michael Olymbios, Minh Luu

    Pages 213-225

18. The Total Artificial Heart

    • Francisco Arabia

    Pages 227-236

19. The Future of Heart Transplantation

    • Jon Kobashigawa

    Pages 237-248

20. Back Matter

    Pages 249-258

    PDF

This is a concise review of up-to-date concepts and techniques in the discipline of heart transplantation. It is a review and reference for practitioners managing patients with advanced heart disease, including patients with end-stage heart failure, mechanical circulatory support or transplant recipients. Heart failure is a major public health issue, with a prevalence of over 5.8 million in the USA, and over 23 million worldwide, and rising. The lifetime risk of developing heart failure is one in five.  Heart failure carries substantial morbidity and mortality, with 5-year mortality that rival those of many cancers.  As heart transplantation remains the best treatment option for patients with end stage heart failure, this primer will provide valuable information and management strategies for physicians caring for these patients.  Also, due to continued shortage in donor organs, heart transplantation is a limited resource – which further underscores the importance of appropriately evaluating patients for transplant candidacy and managing their pre, peri- and post-transplant care for maximum benefit and best outcomes.​

• Antibodies
• Cardiac Transplantation
• Heart Failure
• Immunosuppression
• Mechanical Circulatory Support

“This is a current, concise review of best practices and concepts regarding the pathophysiology and treatment issues in cardiac transplantation. … This succinct resource would be useful for practitioners at all levels of training and practice. From medical students to residents and fellows to cardiologists, the book provides the necessary tools to help manage and treat patients being prepared for, and who undergo, cardiac transplantation. It measures up to any cardiac transplantation review book in the field.” (John Barr Biglane, Doody's Book Reviews, July, 2017)

• Director, Advanced Heart Disease Section, Cedars-Sinai Heart Institute, Los Angeles, USA

  Jon Kobashigawa

Jon Kobashigawa, MD, is the DSL/Thomas D. Gordon professor of Medicine, director of the Advanced Heart Disease Section, director of the Heart Transplant Program and the associate director of the Cedars-Sinai Heart Institute as well as the associate director of the Comprehensive Transplant Center of the Cedars-Sinai Medical Center.

He received his undergraduate degree at Stanford University and earned his medical degree at Mount Sinai School of Medicine in New York. He is a past president of the International Society of Heart and Lung Transplantation, past chair of the American College of Cardiology Committee on Heart Failure and Transplantation, and past member of the United Network of Organ Sharing National Thoracic Committee.

Dr. Kobashigawa is recognized nationally and internationally as a leader in heart transplantation. He has published more than 300 peer-reviewed articles, chapters and monographs in the field of heart failure and transplantation and has chaired several multicenter clinical studies. Dr. Kobashigawa has organized and chaired several International Consensus Conferences to discuss pertinent questions regarding heart failure and heart transplant. He lectures at universities around the world and has mentored several young physicians who have ascended to important academic positions throughout the country.

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