Chikungunya Virus

1. Front Matter

   Pages i-x

   PDF

2. Clinical Syndrome and Therapy

   • Sylvie Abel, André Cabié

   Pages 1-17

3. Host Response and Mechanisms of Subversion of Chikungunya

   • Lisa F. P. Ng, Pierre Roques

   Pages 19-32

4. Epidemiological History of Chikungunya Virus

   • Ann M. Powers

   Pages 33-44

5. Vaccines Against Chikungunya Virus Infection

   • Karl Ljungberg, Beate M. Kümmerer, Pierre Roques, Mariano Esteban, Andres Merits, Peter Liljeström

   Pages 45-62

6. Function of Chikungunya Virus Structural Proteins

   • Stefan W. Metz, Gorben P. Pijlman

   Pages 63-74

7. Functions of Chikungunya Virus Nonstructural Proteins

   • Tero Ahola, Andres Merits

   Pages 75-98

8. Interaction of Chikungunya Virus with the Mosquito Vector

   • Konstantin Tsetsarkin, Lark L. Coffey, Scott C. Weaver

   Pages 99-126

9. Chikungunya Virus Entry and Replication

   • Nathalie Chazal, Laurence Briant

   Pages 127-148

10. Chikungunya Virus-Induced Autophagy and Apoptosis

    • Delphine Judith, Thérèse Couderc, Marc Lecuit

    Pages 149-159

11. Chikungunya Virus Pathogenesis

    • David W. Hawman, Thomas E. Morrison

    Pages 161-183

12. Restriction Factors and Chikungunya Virus

    • Wadie D. Mahauad-Fernandez, Chioma M. Okeoma

    Pages 185-197

This book describes the molecular biology, pathogenesis, epidemiology, and potential strategies for control of chikungunya virus (CHIKV) infection. It offers insight into the structure and functions of CHIKV proteins as they relate to host response, interaction with the arthropod vector, and vaccination. A detailed account of both the epidemiological outlook and the clinical syndrome of CHIKV infection is provided. The complex host-virus interaction and the signaling pathways that mediate such interactions are also covered. Throughout the book, graphics and charts are used to provide stimulating discussion on important findings in the field of chikungunyalogy. The chapters are written with a global perspective by experts of CHIKV from around the world. This project is especially significant given that CHIKV is a pathogen of worldwide public health concern. Although the presence of CHIKV infection is not global yet, worldwide dissemination is predicted in the future due largely to the lack of effective treatment/therapy, efficient control of transmission, and knowledge about mechanisms of pathogenesis. Additionally, globalization of CHIKV is predicated on its mode of dissemination (mosquito vector) and cross border travel and migration.

• CHIKV
• host response
• pathogenesis
• vaccines
• vectors

• Department of Microbiology, University of Iowa, Iowa City, USA

  Chioma M. Okeoma

Chioma M. Okeoma, Ph.D

Department of Microbiology

Carver College of Medicine

University of Iowa

Policies and ethics