Translational Research in Audiology, Neurotology, and the Hearing Sciences

1. Front Matter

   Pages i-xviii

   PDF

2. Perspectives on Auditory Translational Research

   • Colleen G. Le Prell, Edward Lobarinas

   Pages 1-17

3. Current Issues in Clinical and Translational Research in the Hearing Sciences, Audiology, and Otolaryngology

   • Colleen G. Le Prell

   Pages 19-50

4. Auditory Processing Disorder: Biological Basis and Treatment Efficacy

   • Nina Kraus, Samira Anderson

   Pages 51-80

5. Sudden Sensorineural Hearing Loss

   • Scott C. Montgomery, Carol A. Bauer, Edward Lobarinas

   Pages 81-104

6. Development of Drugs for Noise-Induced Hearing Loss

   • Eric D. Lynch, Jonathan Kil, Colleen G. Le Prell

   Pages 105-139

7. Cisplatin-Induced Hearing Loss

   • Kathleen C. M. Campbell, Daniel J. Fox

   Pages 141-164

8. Past, Present, and Future Pharmacological Therapies for Tinnitus

   • Brian L. Allman, Ashley L. Schormans, Marei Typlt, Edward Lobarinas

   Pages 165-195

9. Developing a Molecular Therapeutic for Hearing Loss

   • Hinrich Staecker, Lloyd Klickstein, Douglas E. Brough

   Pages 197-217

10. Photons in the Ear

    • Xiaodong Tan, Nan Xia, Claus-Peter Richter

    Pages 219-239

11. Clinical and Translational Research: Challenges to the Field

    • Colleen G. Le Prell, Edward Lobarinas

    Pages 241-265

Translational Research is the interface between basic science and human clinical application, including the entire process from animal studies to human clinical trials (phases I, II, and III). Translational Research moves promising basic science results from the laboratory to bedside application. Yet, this transition is often the least-defined, least-understood part of the research process. Most scientific training programs provide little or no systematic introduction to the issues, challenges, and obstacles that prevent effective research translation, even though these are the key steps that enable high-impact basic science to ultimately result in significant clinical advances that improve patient outcome.  This volume will provide an overview of key issues in translation of research from “bedside to bench to bedside”, not only from the perspective of the key funding agencies, but also from the scientists and clinicians who are currently involved in the translational research process. It will attempt to offer insight into real-world experience with intellectual property and technology transfer activities that can help move auditory technologies ahead, as scientists and clinicians typically have little or no formal training in these areas. Translational Research in Audiology and the Hearing Sciences will be aimed at graduate students and postdoctoral investigators, as well as professionals and academics. It is intended to function as a high-profile and up-to-date reference work on Translational Research in the auditory sciences, emphasizing research programs in the traditional areas including drugs and devices, as well as less traditional, still emerging, areas such as sensorineural hearing loss, auditory processing disorder, cochlear implants and hearing aids, and tinnitus therapies.

• auditory
• cochlear implant
• hearing loss
• Auditory Processing Disorder
• tinnitus
• Cisplatin-Induced
• photons

• Callier Center for Communication Disorders, University of Texas at Dallas, Dallas, USA

  Colleen G. Le Prell, Edward Lobarinas

• Department of Biology, University of Maryland, College Park, USA

  Arthur N. Popper

• Marine Biological Laboratory, Woods Hole, USA

  Richard R. Fay

Policies and ethics