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Resistance to Photodynamic Therapy in Cancer

  • Book
  • © 2015

Overview

  • Explores mechanisms of action in PDT, the relationship between PDT cytotoxicity and cellular changes
  • Discusses the development of new technological advances in PDT for cancer
  • Offers strategic approaches to reduce multi-drug resistance of tumor cells by PDT
  • Includes supplementary material: sn.pub/extras

Part of the book series: Resistance to Targeted Anti-Cancer Therapeutics (RTACT, volume 5)

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Table of contents (12 chapters)

  1. Introduction

  2. Mechanistic Aspects Involved in Resistance to PDT

  3. Specific Strategies to Sensitize Tumor Cells to PDT

  4. Approaches to Reduce the Multi-Drug Resistance of Tumor Cells by PDT

Keywords

About this book

This volume provides a comprehensive review of resistance induced by photodynamic therapy (PDT) in tumor cells. Understanding the underlying mechanisms in this process leads to the improvement of therapeutic modality, in combination with chemotherapy, immunotherapy, and radiotherapy. Photodynamic therapy is a minimally invasive therapeutic procedure that can exert a selective or preferential cytotoxic activity toward malignant cells. The procedure involves administration of an intrinsically non-toxic photosensitizing agent (PS) followed by irradiation at a wavelength corresponding to a visible absorption band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Studies reveal that PDT can be curative, particularly in early stage tumors and this volume explores the potential of PDT, but also reveals strategic approaches to overcome resistance in tumor cells.

Editors and Affiliations

  • Medical and Biological Sciences, University of Udine, Udine, Italy

    Valentina Rapozzi

  • Prof. Ghiretti, Universita Padova Ist. Biologia Animale, Padova, Italy

    Giulio Jori

About the editors

Giulio Jori is Professor of Biophysics at the University of Padova, Italy. He has been a founding member and President of the European Society for Photobiology. His research interests are focused on basic mechanisms of photodynamic action at a cellular and tissue level, as well as investigations concerning the application of photodynamic therapy for the treatment of tumours and microbial infections. Dr. Jori is Editor-in-chief of Journal of Photochemistry and Photobiology and he was also chairman of the ownership board of the journal Photochemical and Photobiological Sciences. He has been the chief organizer of nine International Symposia on Photodynamic Therapy and Photodiagnosis in Clinical Practice. In addition, he has received an award for excellence in research from the European Society for Photobiology.

Valentina Rapozzi is a Researcher at the University of Udine, Italy. Dr. Rapozzi's research is focused on the antitumoral molecular pathways in photodynamic therapy. She is a member of the European Society for Photobiology, and a member of the Council of the Italian Society of Photobiology.

Bibliographic Information

  • Book Title: Resistance to Photodynamic Therapy in Cancer

  • Editors: Valentina Rapozzi, Giulio Jori

  • Series Title: Resistance to Targeted Anti-Cancer Therapeutics

  • DOI: https://doi.org/10.1007/978-3-319-12730-9

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2015

  • Hardcover ISBN: 978-3-319-12729-3Published: 07 April 2015

  • Softcover ISBN: 978-3-319-38175-6Published: 09 October 2016

  • eBook ISBN: 978-3-319-12730-9Published: 11 December 2014

  • Series ISSN: 2196-5501

  • Series E-ISSN: 2196-551X

  • Edition Number: 1

  • Number of Pages: XV, 248

  • Number of Illustrations: 12 b/w illustrations, 36 illustrations in colour

  • Topics: Cancer Research, Drug Resistance, Molecular Medicine

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