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Translational Neuropsychopharmacology

  • Book
  • © 2016

Overview

Editors:
  1. Trevor W. Robbins

    1. University of Cambridge, Cambridge, UK

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    You can also search for this editor in PubMed   Google Scholar

  2. Barbara J. Sahakian

    1. University of Cambridge, Cambridge, UK

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Translational (neuro)psychopharmacology is the application of basic neuroscience and psychopharmacology to the treatment of psychiatric and neurological disorders - which remain our largest health and socio-economic burden
  • There are currently no books on the subject
  • There are relatively few investigators who have managed to bridge the 'translational gap'; many of them are represented in the current list of possible contributors
  • Includes supplementary material: sn.pub/extras

Part of the book series: Current Topics in Behavioral Neurosciences (CTBN, volume 28)

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics

    • Tatiana M. Kazdoba, Prescott T. Leach, Mu Yang, Jill L. Silverman, Marjorie Solomon, Jacqueline N. Crawley
    Pages 1-52

  3. Translatable and Back-Translatable Measurement of Impulsivity and Compulsivity: Convergent and Divergent Processes

    • Valerie Voon, Jeffrey W. Dalley
    Pages 53-91

  4. Translational Models of Gambling-Related Decision-Making

    • Catharine A. Winstanley, Luke Clark
    Pages 93-120

  5. Translational Research on Nicotine Dependence

    • Mary Falcone, Bridgin Lee, Caryn Lerman, Julie A. Blendy
    Pages 121-150

  6. The Need for Treatment Responsive Translational Biomarkers in Alcoholism Research

    • Markus Heilig, Wolfgang H. Sommer, Rainer Spanagel
    Pages 151-171

  7. On the Road to Translation for PTSD Treatment: Theoretical and Practical Considerations of the Use of Human Models of Conditioned Fear for Drug Development

    • Victoria B. Risbrough, Daniel E. Glenn, Dewleen G. Baker
    Pages 173-196

  8. Translational Approaches Targeting Reconsolidation

    • Marijn C. W. Kroes, Daniela Schiller, Joseph E. LeDoux, Elizabeth A. Phelps
    Pages 197-230

  9. Translational Assessment of Reward and Motivational Deficits in Psychiatric Disorders

    • Andre Der-Avakian, Samuel A. Barnes, Athina Markou, Diego A. Pizzagalli
    Pages 231-262

  10. Affective Biases in Humans and Animals

    • E.S.J. Robinson, J.P. Roiser
    Pages 263-286

  11. Locomotor Profiling from Rodents to the Clinic and Back Again

    • Jared W. Young, Arpi Minassian, Mark A. Geyer
    Pages 287-303

  12. Animal Models of Deficient Sensorimotor Gating in Schizophrenia: Are They Still Relevant?

    • Neal R. Swerdlow, Gregory A. Light
    Pages 305-325

  13. Attention and the Cholinergic System: Relevance to Schizophrenia

    • Cindy Lustig, Martin Sarter
    Pages 327-362

  14. Attentional Set-Shifting Across Species

    • Verity J. Brown, David S. Tait
    Pages 363-395

  15. Relating Translational Neuroimaging and Amperometric Endpoints: Utility for Neuropsychiatric Drug Discovery

    • Jennifer Li, Adam J. Schwarz, Gary Gilmour
    Pages 397-421

  16. Cognitive Translation Using the Rodent Touchscreen Testing Approach

    • M. Hvoslef-Eide, S. R. O. Nilsson, L. M. Saksida, T. J. Bussey
    Pages 423-447

  17. The Paired Associates Learning (PAL) Test: 30 Years of CANTAB Translational Neuroscience from Laboratory to Bedside in Dementia Research

    • Jennifer H. Barnett, Andrew D. Blackwell, Barbara J. Sahakian, Trevor W. Robbins
    Pages 449-474

  18. Experimental Medicine in Psychiatry New Approaches in Schizophrenia, Depression and Cognition

    • Gerard R. Dawson
    Pages 475-497
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Keywords

About this book

This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importance of intermediate staging points between these extremes that depend on suitable translation of findings from animal studies to Phase 1 or Phase 2 studies utilising experimental medicine.  

Reviews

“This book examines the ‘translational gap’ between animal models of neuropsychiatric disease and human studies. … The intended audience is scientists working on problems related to neuropsychopharmacology. … This is an important addition to the literature on translational neurosciences. It is an important contribution to understanding both the current state of this field and its possible future directions.” (Eric Gausche, Doody's Book Reviews, November, 2016)

Editors and Affiliations

  • University of Cambridge, Cambridge, UK

    Trevor W. Robbins, Barbara J. Sahakian

Bibliographic Information

  • Book Title: Translational Neuropsychopharmacology

  • Editors: Trevor W. Robbins, Barbara J. Sahakian

  • Series Title: Current Topics in Behavioral Neurosciences

  • DOI: https://doi.org/10.1007/978-3-319-33913-9

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2016

  • Hardcover ISBN: 978-3-319-33911-5Published: 06 June 2016

  • Softcover ISBN: 978-3-319-81630-2Published: 30 May 2018

  • eBook ISBN: 978-3-319-33913-9Published: 22 September 2016

  • Series ISSN: 1866-3370

  • Series E-ISSN: 1866-3389

  • Edition Number: 1

  • Number of Pages: XII, 498

  • Number of Illustrations: 32 b/w illustrations, 92 illustrations in colour

  • Topics: Neurosciences, Psychopharmacology, Pharmacology/Toxicology

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