Manual of Cardiovascular Proteomics

Editors: Agnetti, Giulio, Lindsey, Merry L., Foster, D. Brian (Eds.)

  • Contains current information on the practical clinical potential of cardiac proteomics
     
    Designed to be read by a broad modern aware audience
     
    Contains numerous helpful and revealing images to help the reader visualize the topic​

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eBook $149.00
price for USA (gross)
  • ISBN 978-3-319-31828-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-3-319-31826-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book fulfils the need to keep up with the high number of innovations in proteomics, and at the same time to warn the readers about the danger of manufacturers and scientists claims around new technologies. Mass spectrometry stands as the core technology in proteomics. The emerging field of targeted proteomics and its potential applications in the cardiovascular arena are also reviewed and discussed. A concluding section highilghts the promise of proteomics in the light of these recent developments.​
As this technique and its applications have undergone remarkable advances in the past years, recent updates on proteomic applications are covered. Another key concept revealed by proteomic technologies is that the extent of protein post-translational modifications (PTMs) as well as their impact on the phenotype has been underestimated by pre-proteomics science. As such, part of the manual focuses on the emerging role of PTMs in basic cardiovascular sciences and in the clinics. 
In fact, there is an emerging consensus that the detailed annotation of protein PTMs could lead to a more in-depth representation of biological systems, translating into more specific targets for therapy as well as biomarkers. Moreover, a recent trend is so-called “targeted proteomics”. The approach was awarded the title of “Method of the Year” by Nature in 2013 (see the editorial by Vivien Marx in 1st issue of Nature in Jan 2013). According to a few proteomic scientists the emphasis should not be placed on generating long lists of proteins but lists of proteins with a true biological meaning. 

About the authors

Giulio Agnetti, PhD is an Assistant Professor of Medicine in the Division of Cardiology at Johns Hopkins University. His research over the past 15 years have focused on the clarification of the molecular mechanisms driving the transition from cardiac hypertrophy to heart failure (HF) utilizing proteomic technologies.

Merry Lindsey, PhD is a Professor of Physiology and Medicine and Director of the Mississippi Center for Heart Research at University of Mississippi. She is working extensively in the field of matrix remodeling and cardiac proteomics. Particular interests include inflammatory and fibrotic mechanisms in the pathogenesis of left ventricular remodeling following myocardial infarction, and cardiac aging.

D. Brian Foster, PhD is an Assistant Professor of Medicine in the Division of Cardiology and Director of the Laboratory of Cardiovascular Biochemistry at The Johns Hopkins University School of Medicine. His lab uses the tools of protein biochemistry and proteomics to tackle fundamental problems in cardiac preconditioning, cardiomyopathy and heart failure.

Table of contents (18 chapters)

  • A Historical Perspective on Cardiovascular Proteomics

    Agnetti, Giulio (et al.)

    Pages 1-14

  • Basic Concepts in Mass Spectrometry and Protein Quantitation

    Cosme, Jake (et al.)

    Pages 15-32

  • How to Design a Cardiovascular Proteomics Experiment

    Lindsey, Merry L. (et al.)

    Pages 33-57

  • Organelle, Protein and Peptide Fractionation in Cardiovascular Proteomics

    Miller, Mickey R. (et al.)

    Pages 59-104

  • Vascular Proteomics

    Martin-Ventura, Jose Luis (et al.)

    Pages 105-122

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-3-319-31828-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-3-319-31826-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Manual of Cardiovascular Proteomics
Editors
  • Giulio Agnetti
  • Merry L. Lindsey
  • D. Brian Foster
Copyright
2016
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-31828-8
DOI
10.1007/978-3-319-31828-8
Hardcover ISBN
978-3-319-31826-4
Edition Number
1
Number of Pages
XVI, 430
Number of Illustrations and Tables
7 b/w illustrations, 58 illustrations in colour
Topics