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  • Book
  • © 2016

Metallothioneins in Normal and Cancer Cells

  • Illustrates the complete involvement of Metallothioneins in multiple biological processes
  • Explains how Metallothioneins play an important role in cell senescence progression
  • Clinical Application: Highlights the role of Metallothioneins in carcinogenesis and various pathological processes
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Anatomy, Embryology and Cell Biology (ADVSANAT, volume 218)

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Table of contents (5 chapters)

  1. Front Matter

    Pages i-xii
  2. Introduction

    • Piotr Dziegiel, Bartosz Pula, Christopher Kobierzycki, Mariusz Stasiolek, Marzenna Podhorska-Okolow
    Pages 1-2
  3. Metallothioneins: Structure and Functions

    • Piotr Dziegiel, Bartosz Pula, Christopher Kobierzycki, Mariusz Stasiolek, Marzenna Podhorska-Okolow
    Pages 3-20
  4. Metallothionein-3

    • Piotr Dziegiel, Bartosz Pula, Christopher Kobierzycki, Mariusz Stasiolek, Marzenna Podhorska-Okolow
    Pages 21-27
  5. The Role of Metallothioneins in Carcinogenesis

    • Piotr Dziegiel, Bartosz Pula, Christopher Kobierzycki, Mariusz Stasiolek, Marzenna Podhorska-Okolow
    Pages 29-63
  6. Metallothioneins and Immune Function

    • Piotr Dziegiel, Bartosz Pula, Christopher Kobierzycki, Mariusz Stasiolek, Marzenna Podhorska-Okolow
    Pages 65-77
  7. Back Matter

    Pages 79-117

About this book

This book describes the structures of Metallothionein (MT) family members and the cellular functions of MT-1, MT-2 and MT-4 isoforms, as well as provides insights into divergent biological roles of MT-3. The authors explain the involvement of MT molecules in various processes related to carcinogenesis, including an organ-specific presentation of current data concerning their potential impact on the progression of various tumors and the regulatory role of MT family members in the function of the immune system. 

Reviews

“This is a concise monograph on the pathophysiological role of molecules called metallothioneins in cancerous cells including GI, GU, renal, endocrine, and CNS systems. Normal physiology of these compounds is described well. The biochemical pathways, signal transduction, and cellular mechanisms are discussed in depth. … I recommend this book to those interested in physiology and cancer research. Students, fellows and experts will all find this reference beneficial.” (Joseph J. Grenier, Amazon.com, June, 2016)

Authors and Affiliations

  • Dept. of Histology and Embryology, Wroclaw Medical University, Wroclaw, Poland

    Piotr Dziegiel, Christopher Kobierzycki, Marzenna Podhorska-Okolow

  • Department of Histology and Embryology, Wroclaw Medical University, Wroclaw, Poland

    Bartosz Pula

  • Polish Mother's Mem. Hospital Res. Inst., Dept. of Neurology, Lodz, Poland

    Mariusz Stasiolek

Bibliographic Information

  • Book Title: Metallothioneins in Normal and Cancer Cells

  • Authors: Piotr Dziegiel, Bartosz Pula, Christopher Kobierzycki, Mariusz Stasiolek, Marzenna Podhorska-Okolow

  • Series Title: Advances in Anatomy, Embryology and Cell Biology

  • DOI: https://doi.org/10.1007/978-3-319-27472-0

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2016

  • Softcover ISBN: 978-3-319-27471-3Published: 16 February 2016

  • eBook ISBN: 978-3-319-27472-0Published: 04 February 2016

  • Series ISSN: 0301-5556

  • Series E-ISSN: 2192-7065

  • Edition Number: 1

  • Number of Pages: XII, 117

  • Number of Illustrations: 2 b/w illustrations, 11 illustrations in colour

  • Topics: Cell Biology, Immunology, Cancer Research

Buy it now

Buying options

eBook USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access