Overview
- A comprehensive investigation into the ATPase regulation of Membrane Na+-K+ ATPase
- Explores the specific inhibitors and molecular probes for membrane ATPases to improve the therapy of various diseases
- An informative resource to improve diverse ATPase therapeutic approaches of life threatening diseases
Part of the book series: Advances in Biochemistry in Health and Disease (ABHD, volume 15)
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Table of contents (24 chapters)
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Front Matter
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Functional and Signaling Aspects
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Front Matter
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Modulatory and Regulatory Aspects
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Front Matter
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Keywords
About this book
Na+-K+ ATPase or Na-pump ATPase, a member of “P”-type ATPase superfamily, is characterized by association of multiple isoforms mainly of it’s α- and β- subunits. At present four different α- (α-1,α-2,α-3 and α-4) and three β- (β-1, β-2, and β-3) isoforms have been identified in mammalian cells and their differential expressions are tissue specific. Regulation of Na+-K+ ATPase activity is an important but a complex process, which involves short-term and long-term mechanisms. Short-term regulation of Na+-K+ ATPase is either mediated by changes in intracellular Na+ concentrations that directly affect the Na+-pump activity or by phosphorylation/dephosphorylation-mediated by some stimulants leading to changes in its expression and transport properties. On the other hand, long-term regulation of Na+-K+ ATPase is mediated by hormones, such as mineralocorticoids and thyroid hormones, which cause changes in the transcription of genes of α- and β- subunits leading to an increased expression in the level of Na+-pump. Several studies have revealed a relatively new type of regulation that involves the association of small, single span membrane proteins with this enzyme. These proteins belong to the FXYD family, the members of which share a common signature sequence encompassing the transmembra
ne domain adjacent to the isoform(s) of α-β subunits of Na+-K+ ATPase. Considering the extraordinary importance of Na+-K+ ATPase in cellular function, several internationally established investigators have contributed their articles in the monograph entitled “Regulation of Membrane Na+-K+ ATPase” for inspiring young scientists and graduate students to enrich their knowledge on the enzyme, and we are sure that this book will soon be considered as a comprehensive scientific literature in the area of Na+-K+ ATPase regulation in health and disease.Editors and Affiliations
Bibliographic Information
Book Title: Regulation of Membrane Na+-K+ ATPase
Editors: Sajal Chakraborti, Naranjan S Dhalla
Series Title: Advances in Biochemistry in Health and Disease
DOI: https://doi.org/10.1007/978-3-319-24750-2
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing AG, part of Springer Nature 2016
Hardcover ISBN: 978-3-319-24748-9Published: 22 December 2015
Softcover ISBN: 978-3-319-79672-7Published: 27 March 2019
eBook ISBN: 978-3-319-24750-2Published: 16 December 2015
Series ISSN: 2512-2142
Series E-ISSN: 2512-2150
Edition Number: 1
Number of Pages: XI, 436
Number of Illustrations: 56 b/w illustrations, 44 illustrations in colour
Topics: Protein Structure, Membrane Biology, Protein Science, Atomic/Molecular Structure and Spectra, Molecular Medicine