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  • © 2015

Orexin and Sleep

Molecular, Functional and Clinical Aspects

  • Provides comprehensive overview of the field, in-depth coverage of basic and clinical research
  • Presents established theories as well as the most recent developments in neurology, psychiatry, neuroendocrinology, neuroanatomy, neuropharmacology, and molecular biology
  • Shares highly applicable knowledge for sleep research and clinical practice, with proven strategies for difficult-to-treat patients with narcolepsy and comorbid mental disturbances
  • Includes supplementary material: sn.pub/extras

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-xiv
  2. History of Orexin Research

    • Takeshi Sakurai
    Pages 1-25
  3. The Hypocretin Story

    • Luis de Lecea
    Pages 27-35
  4. Input and Output Systems of Orexin Neurons

    • Takatoshi Mochizuki, Kyoko Yoshida-Court
    Pages 37-52
  5. Orexin Receptor Functions in the Ascending Arousal System

    • Christopher S. Leonard, Masaru Ishibashi
    Pages 67-80
  6. Optogenetic Dissection of Sleep-Wake Circuits in the Brain

    • Thomas C. Gent, Antoine R. Adamantidis
    Pages 93-105
  7. Orexin, Alcohol and Sleep Homeostasis

    • Rishi Sharma, Pradeep Sahota, Mahesh M. Thakkar
    Pages 137-164
  8. Role of Orexin on Sleep: Interactions with Other Neurotransmitter Systems

    • Pablo Torterolo, Jaime Monti, S. R. Pandi-Perumal
    Pages 181-202
  9. Animal Models of Narcolepsy

    • Takeshi Sakurai
    Pages 203-212
  10. Symptomatic Narcolepsy or Hypersomnia, with and Without Orexin (Hypocretin) Deficiency

    • T. Kanbayashi, A. Imanishi, Y. Ohmori, Y. Sagawa, Y. Takahashi, M. Omokawa et al.
    Pages 213-258
  11. Narcolepsy and Idiopathic Hypersomnia

    • Seiji Nishino
    Pages 259-287
  12. Hypocretin/Orexin Pathology in Human Narcolepsy with and Without Cataplexy

    • Thomas C. Thannickal, Jerome M. Siegel
    Pages 289-298
  13. A New Class of Hypnotic Compounds for the Treatment of Insomnia: The Dual Orexin Receptor Antagonists

    • Jason M. Uslaner, John J. Renger, Paul J. Coleman, Chris J. Winrow
    Pages 323-338
  14. Pathway and Effect of Intranasal Orexin

    • Sara Lena Weinhold, Robert Göder, Paul Christian Baier
    Pages 339-351
  15. Hypocretin (Orexin) Cell Transplantation as a New Therapeutic Approach in Narcolepsy

    • Oscar Arias-Carrión, Andrea Herrera-Solís, Alwin Poot-Aké, Ramsés Jiménez-Moreno, Eric Murillo-Rodríguez
    Pages 353-362

About this book

This volume is intended for neuropharmacologists, psychopharmacologists, pharmacologists, pharmacists, sleep researchers, translational neuroscience researchers, and other basic researchers and clinical scientists interested in an interdisciplinary approach to sleep medicine. The level of the book is aiming at CNS researchers, drug development scientists, basic and clinical sleep researchers, as well as senior medical students and fellows in psychiatry and neurology. Orexin and Sleep provides a unique resource, giving a comprehensive and highly readable summary of the basic concepts in orexin biology and pharmacology along with clinical applications in sleep medicine in general, and narcolepsy in particular.

Reviews

“This is an up-to-date look at these hypothalamic neuropeptides and how we have come to understand their wide range of neuroregulatory roles. … This is highly technical book that reviews in detail the research that has led to the discovery and understanding of the orexin neuropeptides and their role in a wide range of neuromodulatory systems. … provide some insights into how manipulation of this system may result in therapeutic interventions for a number of neurological and psychiatric conditions.” (Michael Easton, Doody’s Book Reviews, February, 2016)

Editors and Affiliations

  • Dept. of Molecular Neurosci. & Integrati, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan

    Takeshi Sakurai

  • Somnogen Canada Inc, President and Chief Executive Officer, Toronto, Canada

    S.R. Pandi-Perumal

  • Dept. Pharmacology & Therapeutics, Clinics Hospital Montevideo School of Medicine, Montevideo, Uruguay

    Jaime M. Monti

About the editors

Takeshi Sakurai, MD, PhD

Takeshi Sakurai is a professor in the Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University (Japan). He obtained his M.D. and Ph.D. from the University of Tsukuba and received his postdoctoral training at the Howard Hughes Medical Institute at the University of Texas Southwestern Medical Center, Dallas, USA. The goal of his work is to identify novel neuropeptides and define their physiological roles. He is especially interested in neuropeptides involved in homeostatic processes and innate behaviors such as feeding, autonomic function, emotion, and sleep and wakefulness states. In recent years, he has focused on identifying the input and output systems of orexin neurons to reveal the neuronal network that plays an important role in regulating  sleep and wakefulness states.

S.R. Pandi-Perumal, MSc.,

Pandi-Perumal is the President and Chief Executive Officer of Somnogen Canada Inc, a Canadian Corporation. He is a well-recognized sleep researcher both nationally and internationally, and has authored many publications. His general area of research interest includes sleep and biological rhythms. He is a well-known editor in the field of sleep medicine and has edited over 20 volumes dealing with various sleep-related topics. He had an honorable mention in the New York Times in 2004. India International Friendship Society awarded 'Bharat Gaurav award' on January 12, 2013.

Jaime M. Monti, MD

Jaime M. Monti has obtained his MD from Uruguay and subsequently he had his early career trainings at Stanford University and National Institutes of Mental Health. He is a member of the International College of Neuropsychopharmacology, the Sleep Research Society (USA), the European Sleep Research Society, and the Argentinian Society of Sleep Medicine. Contributed

and served at various capacities in these societies. He has published over 150 peer-reviewedscientific papers and he has edited several volumes related to sleep. Over the years, he has won several prestigious awards for his research, including the Claude Bernard Award (Clinical Sleep Research) from the Government of France, and the Schering Award for Basic Sleep Research, in Germany.

Bibliographic Information

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access