Recent Results in Cancer Research

Chromosomal Instability in Cancer Cells

Editors: Ghadimi, B. Michael, Ried, Thomas (Eds.)

  • Reviews up-to-date knowledge of chromosomal instability in cancer
  • Examines strategies to harness this information for the better treatment of cancer patients
  • Written by acknowledged experts in the field
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eBook $84.99
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  • ISBN 978-3-319-20291-4
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Hardcover $109.00
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  • ISBN 978-3-319-20290-7
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Softcover $109.00
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  • ISBN 978-3-319-34962-6
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About this book

This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.

Table of contents (9 chapters)

  • DNA Repair and Chromosomal Translocations

    Bohlander, Stefan K. (et al.)

    Pages 1-37

  • CINcere Modelling: What Have Mouse Models for Chromosome Instability Taught Us?

    Simon, Judith E. (et al.)

    Pages 39-60

  • Telomere Dysfunction, Chromosomal Instability and Cancer

    Meena, Jitendra (et al.)

    Pages 61-79

  • Genetic Instability and Disease Prognostication

    Gemoll, Timo (et al.)

    Pages 81-94

  • Causes of Chromosomal Instability

    Bastians, Holger

    Pages 95-113

Buy this book

eBook $84.99
price for USA (gross)
  • ISBN 978-3-319-20291-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $109.00
price for USA
  • ISBN 978-3-319-20290-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $109.00
price for USA
  • ISBN 978-3-319-34962-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Chromosomal Instability in Cancer Cells
Editors
  • B. Michael Ghadimi
  • Thomas Ried
Series Title
Recent Results in Cancer Research
Series Volume
200
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-20291-4
DOI
10.1007/978-3-319-20291-4
Hardcover ISBN
978-3-319-20290-7
Softcover ISBN
978-3-319-34962-6
Series ISSN
0080-0015
Edition Number
1
Number of Pages
VII, 224
Number of Illustrations and Tables
39 illustrations in colour
Topics