SH Domains

Structure, Mechanisms and Applications

Editors: Kurochkina, Natalya (Ed.)

  • ​Provides state-of-the-art review on the important roles of SH domains
  • Gives outlook on future applications in stem cell therapy and biomaterials
  • Written by international experts from the field
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eBook $119.00
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-3-319-20098-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.00
price for USA
valid through November 5, 2017
  • ISBN 978-3-319-20097-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $159.00
price for USA
valid through November 5, 2017
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 4, 2016
  • ISBN 978-3-319-37252-5
  • Free shipping for individuals worldwide
About this book

This book covers structure, function, and important roles of the SH domains, structure-function relationships, the versatile nature of their action, mechanisms of aggregation, specificity of interactions, impact of mutations on protein functional dysregulation, and cell signaling. Their involvement in various cellular processes such as migration, invasiveness, actin reorganization, shaping spines, determination of the morphology assembly of fibrils, and mechanotransduction makes these molecules attractive drug targets. Substrates, inhibitors and activators of PTKs present a wide variety of therapeutic agents in the context of delivering treatments for numerous pathologies. The new emerging field of stem cell therapies and design of biomaterials for treatments relies on the directed regulation of stem cell growth, differentiation and morphology, as well as the production of biomimetic scaffolds that respond to programmed signals. Advances in deciphering the mechanisms of action of these important molecules will lead to the implementation and success of their vital applications.

Table of contents (11 chapters)

  • SH3 Domains as Suitable Models to Study Amyloid Aggregation

    Morel, Bertrand (et al.)

    Pages 1-15

  • SH Domain Proteins in Plants: Roles in Signaling Transduction and Membrane Trafficking

    Zhuang, Xiaohong (et al.)

    Pages 17-33

  • Versatility of SH3 Domains in the Cellular Machinery

    Azuaga, Ana I. (et al.)

    Pages 35-69

  • Structure-Function Relationship of Bacterial SH3 Domains

    Kamitori, Shigehiro (et al.)

    Pages 71-89

  • Activation of PI3K by Thyroid Hormone Nuclear Receptors

    Park, Jeong Won (et al.)

    Pages 91-110

Buy this book

eBook $119.00
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-3-319-20098-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.00
price for USA
valid through November 5, 2017
  • ISBN 978-3-319-20097-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $159.00
price for USA
valid through November 5, 2017
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 4, 2016
  • ISBN 978-3-319-37252-5
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
SH Domains
Book Subtitle
Structure, Mechanisms and Applications
Editors
  • Natalya Kurochkina
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-20098-9
DOI
10.1007/978-3-319-20098-9
Hardcover ISBN
978-3-319-20097-2
Softcover ISBN
978-3-319-37252-5
Edition Number
1
Number of Pages
VIII, 253
Number of Illustrations and Tables
22 b/w illustrations, 30 illustrations in colour
Topics