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Texts in Computational Science and Engineering

A Guide to Numerical Modelling in Systems Biology

Authors: Deuflhard, Peter, Röblitz, Susanna

  • Mathematics without theorems in clear orientation towards systems biology 
  • Many illustrative examples to explain details
  • Guide to software indicating its strengths and weaknesses
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eBook $39.99
price for USA (gross)
  • ISBN 978-3-319-20059-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $49.99
price for USA
  • ISBN 978-3-319-20058-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $49.99
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 4, 2016
  • ISBN 978-3-319-36882-5
  • Free shipping for individuals worldwide
About this Textbook

This book is intended for students of computational systems biology with only a limited background in mathematics. Typical books on systems biology merely mention algorithmic approaches, but without offering a deeper understanding. On the other hand, mathematical books are typically unreadable for computational biologists. The authors of the present book have worked hard to fill this gap. The result is not a book on systems biology, but on computational methods in systems biology. This book originated from courses taught by the authors at Freie Universität Berlin. The guiding idea of the courses was to convey those mathematical insights that are indispensable for systems biology, teaching the necessary mathematical prerequisites by means of many illustrative examples and without any theorems. The three chapters cover the mathematical modelling of biochemical and physiological processes, numerical simulation of the dynamics of biological networks and identification of model parameters by means of comparisons with real data. Throughout the text, the strengths and weaknesses of numerical algorithms with respect to various systems biological issues are discussed. Web addresses for downloading the corresponding software are also included.

About the authors

Peter Deuflhard, founder of ZIB and co-founder of MATHEON in Berlin, has written successful books in numerical analysis and scientific computing (three of them with Springer).

Susanna Röblitz is Head of the research group Computational Systems Biology at ZIB and professor for Applied Mathematics and Bioinformatics at FU Berlin.

 

Reviews

“This book is structured in three chapters covering the ODE modeling for the identification and characterization of biological networks, the handling of numerical simulations for the proposed ODE models and the corresponding parameters identification, respectively. … included a list of numerical algorithms and software packages that facilitate the understanding of the ODE-related problems. … written in an accessible manner, with plenty of examples, making it a valuable addition to the series of textbooks in computational science and engineering.” (Irina Ioana Mohorianu, zbMATH, Vol. 1325.92001, 2016)

“It focuses almost solely on the mundane mathematical topic of ordinary differential equations (ODEs) and their parameter estimation … . the prime readership for this volume is to be found more amongst advanced researchers in systems biology trying to find reasons for unstable results of some ODE simulation or identification packages.” (L.-F. Pau, Computing Reviews, November, 2015)


Table of contents (3 chapters)

  • ODE Models for Systems Biological Networks

    Deuflhard, Peter (et al.)

    Pages 1-32

  • Numerical Simulation of ODE Models

    Deuflhard, Peter (et al.)

    Pages 33-87

  • Parameter Identification in ODE Models

    Deuflhard, Peter (et al.)

    Pages 89-138

Buy this book

eBook $39.99
price for USA (gross)
  • ISBN 978-3-319-20059-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $49.99
price for USA
  • ISBN 978-3-319-20058-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $49.99
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 4, 2016
  • ISBN 978-3-319-36882-5
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
A Guide to Numerical Modelling in Systems Biology
Authors
Series Title
Texts in Computational Science and Engineering
Series Volume
12
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-20059-0
DOI
10.1007/978-3-319-20059-0
Hardcover ISBN
978-3-319-20058-3
Softcover ISBN
978-3-319-36882-5
Series ISSN
1611-0994
Edition Number
1
Number of Pages
X, 168
Number of Illustrations and Tables
9 b/w illustrations, 33 illustrations in colour
Topics