Current Topics in Microbiology and Immunology

The Future of HIV-1 Therapeutics

Resistance Is Futile?

Editors: Torbett, Bruce, Goodsell, David S., Richman, Douglas (Eds.)

  • Highlights the identification and evaluation of antiretrovirals that may be less prone in selecting for HIV-1 resistance
  • Covers recent advances in the identification and function of small molecule inhibitors that target novel HIV-1 regulatory and structural components to disrupt replication and alter the state of viral latency
  • Offers up-to-date information for virologists, infectious disease specialists, and chemical biologists on HIV-1 antiretrovirals currently in use
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eBook $149.00
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-3-319-18518-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
valid through November 5, 2017
  • ISBN 978-3-319-18517-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
valid through November 5, 2017
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 4, 2016
  • ISBN 978-3-319-37450-5
  • Free shipping for individuals worldwide
About this book

This volume thoroughly covers HIV-1 antiretrovirals currently in clinical use, together with their advantages and limitations. HIV-1 inhibitor resistance is discussed in detail, and critical assessments as to what will be required of future antiretrovirals in order to halt viral replication, reduce viral resistance, and alter the state of viral latency are presented. Experts at the forefront of HIV-1 research provide overviews of approaches from the fields of virology, chemical biology and structural biology for obtaining small molecule inhibitors that target viral regulatory and structural components at multiple points in the viral lifecycle. The individual chapters will appeal to scientists and clinicians alike.

Reviews

“The book does a fantastic job of addressing new approaches to inhibit HIV-1. … this is a useful book that can be used by researchers, HIV clinicians, and medicinal chemists interested in investigating new molecules for the treatment of HIV-1. It addresses novel areas that have no chemical entities that are FDA approved. There are no books that compete with this one.” (Christopher J. Destache, Doody's Book Reviews, September, 2015)

“This book includes 8 comprehensive, heavily referenced chapters on antiretroviral drug development. … a comprehensive, readable review of a subject that brings together 2 or more decades of molecular virology research and drug development. … the chapters in this book are likely to be, for the next several years, highly useful and popular starting points for learning about new areas in HIV drug development.” (Robert W. Shafer, Clinical Infectious Diseases, September, 2015)


Table of contents (9 chapters)

  • HIV Therapy—The State of ART

    Looney, David (et al.)

    Pages 1-29

  • Computational Challenges of Structure-Based Approaches Applied to HIV

    Forli, Stefano (et al.)

    Pages 31-51

  • Nucleocapsid Protein: A Desirable Target for Future Therapies Against HIV-1

    Mori, Mattia (et al.)

    Pages 53-92

  • HIV-1 Integrase Multimerization as a Therapeutic Target

    Feng, Lei (et al.)

    Pages 93-119

  • Targeting HIV Transcription: The Quest for a Functional Cure

    Mousseau, Guillaume (et al.)

    Pages 121-145

Buy this book

eBook $149.00
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-3-319-18518-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
valid through November 5, 2017
  • ISBN 978-3-319-18517-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
valid through November 5, 2017
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 4, 2016
  • ISBN 978-3-319-37450-5
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
The Future of HIV-1 Therapeutics
Book Subtitle
Resistance Is Futile?
Editors
  • Bruce Torbett
  • David S. Goodsell
  • Douglas Richman
Series Title
Current Topics in Microbiology and Immunology
Series Volume
389
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-18518-7
DOI
10.1007/978-3-319-18518-7
Hardcover ISBN
978-3-319-18517-0
Softcover ISBN
978-3-319-37450-5
Series ISSN
0070-217X
Edition Number
1
Number of Pages
X, 254
Topics