Biomolecular Interfaces

Interactions, Functions and Drug Design

Authors: Fernandez Stigliano, Ariel

  • Casts new light on bio molecular interactions
  • Will be of interest to researchers and graduate students in chemistry, biophysics and biomedical engineering
  • Problems and solutions in each frontier topic allow readers to broaden their understanding
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eBook $69.99
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-3-319-16850-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $99.00
price for USA
valid through November 5, 2017
  • ISBN 978-3-319-16849-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this Textbook

The book focuses on the aqueous interface of biomolecules, a vital yet overlooked area of biophysical research. Most biological phenomena cannot be fully understood at the molecular level without considering interfacial behavior.

The author presents conceptual advances in molecular biophysics that herald the advent of a new discipline, epistructural biology, centered on the interactions of water and bio molecular structures across the interface. The author introduces powerful theoretical and computational resources in order to address fundamental topics such as protein folding, the physico-chemical basis of enzyme catalysis and protein associations. On the basis of this information, a multi-disciplinary approach is used to engineer therapeutic drugs and to allow substantive advances in targeted molecular medicine. This book will be of interest to scientists, students and practitioners in the fields of chemistry, biophysics and biomedical engineering.

About the authors

The author is Ariel Fernandez Stigliano, who is an Argentinian–American theoretical chemist and mathematician, and heads his own pharmaceutical consultancy, Ariel Fernandez Innovation, at the Argentine National Scientific and Technical Research Council (CONICET) and at Collegium Basilea, the Institute of Advanced Study in Basel, Switzerland. Addresses: Avenida del Libertador 1092 – Piso 1 Buenos Aires 1112, Argentina 1419 Montrose Blvd. #305 Houston, TX 77019, USA Current Positions: * Senior Investigator, Argentine National Research Council (CONICET) (2011-). Instituto Argentino de Matemática, “Alberto P. Calderón", 1083 Buenos Aires, Argentina * Honorary Investigator, Collegium Basilea, Institute of Advanced Study, CH 4053 Basel, Switzerland (2006-) * Visiting Professor, National Tsing-Hua University, Hsinchu, Republic of China (2010-) · President, AF Innovation, SRL, a Pharmaceutical Consultancy (2010-). * Vice president and Chief Scientific Officer at Ariel Fernandez Consultancy, GmbH, a Biotechnology firm specialized in dynamic molecular design (2013-)

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Table of contents (15 chapters)

  • The Aqueous Interface of a Soluble Protein or the Birth of Epistructural Biology

    Fernández Stigliano, Ariel

    Pages 1-33

  • Electrostatic Exploration of Biomolecular Interfaces: The Chemical Function of Interfacial Water

    Fernández Stigliano, Ariel

    Pages 35-51

  • Semiempirical Solution to the Protein Folding Problem Through a Combination of Structural and Epistructural Approaches

    Fernández Stigliano, Ariel

    Pages 53-82

  • Packing Defects and Protein Hydration: Dynamics of the Aqueous Interface

    Fernández Stigliano, Ariel

    Pages 83-96

  • Proteins in the Order–Disorder Twilight: Unstable Interfaces Promote Protein Aggregation

    Fernández Stigliano, Ariel

    Pages 97-126

Buy this book

eBook $69.99
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-3-319-16850-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $99.00
price for USA
valid through November 5, 2017
  • ISBN 978-3-319-16849-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Biomolecular Interfaces
Book Subtitle
Interactions, Functions and Drug Design
Authors
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-16850-0
DOI
10.1007/978-3-319-16850-0
Hardcover ISBN
978-3-319-16849-4
Edition Number
1
Number of Pages
XIX, 372
Number of Illustrations and Tables
86 b/w illustrations, 59 illustrations in colour
Topics