Editors:
- CK2 is a potential target of drug development for improved cancer therapy
- State-of-the-art information on the critical role of CK2 in cellular function and cancer biology?
- Crucial tool for post-graduate students and investigators in the field of cancer biology
Part of the book series: Advances in Biochemistry in Health and Disease (ABHD, volume 12)
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Table of contents (20 chapters)
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Front Matter
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Regulation and Structure–Function Studies of CK2
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Front Matter
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CK2 Control of Organismal and Cellular Functions
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Front Matter
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Function of CK2 in Cancer and Its Therapeutic Targeting
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Front Matter
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About this book
Editors and Affiliations
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Department of Laboratory Medicine and Pathology, University of Minnesota Medical School and Minneapolis VA Health Care System, Minneapolis, USA
Khalil Ahmed
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Dept of Biochemistry & Molecular Biology, University of Southern Denmark, Odense, Denmark
Olaf-Georg Issinger
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Department of Molecular Biology, The John Paul II Catholic U. of Lublin Institute of Biotechnology, Lublin, Poland
Ryszard Szyszka
About the editors
Dr. Khalil Ahmed is a Professor at the University of Minnesota, and a Senior Research Career Scientist at Minneapolis VA Health Care System, Minneapolis, Minnesota, U.S.A. He has a long history of studies on the functional biology of protein kinase CK2 in normal and neoplastic cells. He originally described the signal mediated dynamic shuttling of CK2 in the cell, and discovered the role of CK2 as a suppressor of apoptosis. His current research is focused on the mechanism of CK2 regulation of cell death. He is also studying the development of molecular therapeutic strategies using a nanomedicine approach for treatment of prostate and other cancers.
Dr. Olaf-Georg Issinger is a Professor at the University of Southern Denmark, Odense, Denmark. He has been involved in the initial cloning and characterization of protein kinase CK2, a prerequisite for the elucidation of its structure in the absence and presence of specific interaction molecules. His current research focuses on the exploration of cellular signaling pathways in cell lines with respect to the role of various protein kinases using newly characterized kinase inhibitors identified by screening small chemical compound libraries.
Dr. Ryszard Szyszka is a Professor at the John Paul II Catholic University of Lublin, Poland. He is head of the Department of Molecular Biology and Dean of the Faculty of Biotechnology and Environmental Sciences. His research is focused on the identification and characterization of new substrates of protein kinase CK2 from Saccharomyces cerevisiae. Further areas of interest include the structure and regulation of yeast CK2, and discovery of novel CK2 inhibitors.
Bibliographic Information
Book Title: Protein Kinase CK2 Cellular Function in Normal and Disease States
Editors: Khalil Ahmed, Olaf-Georg Issinger, Ryszard Szyszka
Series Title: Advances in Biochemistry in Health and Disease
DOI: https://doi.org/10.1007/978-3-319-14544-0
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing Switzerland 2015
Hardcover ISBN: 978-3-319-14543-3Published: 25 March 2015
Softcover ISBN: 978-3-319-37986-9Published: 06 October 2016
eBook ISBN: 978-3-319-14544-0Published: 03 March 2015
Series ISSN: 2512-2142
Series E-ISSN: 2512-2150
Edition Number: 1
Number of Pages: XXIII, 378
Number of Illustrations: 31 b/w illustrations, 60 illustrations in colour
Topics: Cancer Research, Protein Science, Apoptosis