Editors:
- Reviews exhaustively the key recent research regarding bioactive biomaterials and the mechanisms through which they influence the local bone and joint environment to induce tissue repair and regeneration
- Maximizes reader insights into the importance of biomaterials composition, surface topography, architectural and mechanical properties in providing support for tissue regeneration
- Demonstrates the interconnectedness of biomaterials, bone/cartilage cells, growth factors and stem cells
- Includes supplementary material: sn.pub/extras
Part of the book series: Mechanical Engineering Series (MES)
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Table of contents (13 chapters)
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Front Matter
About this book
Reviewing exhaustively the current state of the art of tissue engineering strategies for regenerating bones and joints through the use of biomaterials, growth factors and stem cells, along with an investigation of the interactions between biomaterials, bone cells, growth factors and added stem cells and how together skeletal tissues can be optimised, this book serves to highlight the importance of biomaterials composition, surface topography, architectural and mechanical properties in providing support for tissue regeneration.
Maximizing reader insights into the importance of the interplay of these attributes with bone cells (osteoblasts, osteocytes and osteoclasts) and cartilage cells (chondrocytes), this book also provides a detailed reference as to how key signalling pathways are activated. The contribution of growth factors to drive tissue regeneration and stem cell recruitment is discussed along with a review the potential and challenges of adult or embryonic mesenchymal stem cells to further enhance the formation of new bone and cartilage tissues.
This book serves to demonstrate the interconnectedness of biomaterials, bone/cartilage cells, growth factors and stem cells in determining the regenerative process and thus the clinical outcome.
Editors and Affiliations
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Tissue Engineering and Biomaterials Research Unit, University of Sydney, Sydney, Australia
Hala Zreiqat
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Biomedical Engineering, University of Sydney, Sydney, Australia
Colin R. Dunstan
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Department of Developmental Biology, Harvard School of Dental Medicine, Boston, USA
Vicki Rosen
About the editors
Colin Dunstan is an expert in bone cell biology and the interrelationships between bone cells and their microenvironment.
Vicki Rosen is an expert is studying the physiological roles that bone morphogenetic proteins (BMPs) play in the development, maintenance, and repair of musculoskeletal tissues (bone, cartilage, tendon, ligament, meniscus, muscle).
Bibliographic Information
Book Title: A Tissue Regeneration Approach to Bone and Cartilage Repair
Editors: Hala Zreiqat, Colin R. Dunstan, Vicki Rosen
Series Title: Mechanical Engineering Series
DOI: https://doi.org/10.1007/978-3-319-13266-2
Publisher: Springer Cham
eBook Packages: Engineering, Engineering (R0)
Copyright Information: Springer International Publishing Switzerland 2015
Hardcover ISBN: 978-3-319-13265-5Published: 16 December 2014
Softcover ISBN: 978-3-319-37971-5Published: 10 September 2016
eBook ISBN: 978-3-319-13266-2Published: 05 December 2014
Series ISSN: 0941-5122
Series E-ISSN: 2192-063X
Edition Number: 1
Number of Pages: VI, 254
Number of Illustrations: 48 b/w illustrations
Topics: Biomedical Engineering and Bioengineering, Biomaterials, Medical Microbiology, Biological and Medical Physics, Biophysics