Cancer Metastasis - Biology and Treatment

Genomic Instability and Cancer Metastasis

Mechanisms, Emerging Themes, and Novel Therapeutic Strategies

Editors: Maxwell, Chris, Roskelley, Cal (Eds.)

  • Connects cancer metastasis with genomic instability in a comprehensive manner
  • Outlines the fundamental mechanisms responsible for these cellular and tissue phenotypes
  • Reviews emerging themes and highlights new therapeutic approaches to overcome the unique challenges presented by the heterogeneous and metastatic tumor
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Buy this book

eBook $129.00
price for USA (gross)
  • ISBN 978-3-319-12136-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA
  • ISBN 978-3-319-12135-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.99
price for USA
  • ISBN 978-3-319-35295-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse. This book connects cancer metastasis with genomic instability in a comprehensive manner. Section 1 outlines the fundamental mechanisms responsible for these cellular and tissue phenotypes. Section 2 discusses in silico, in vitro, and in vivo models used for the experimental study of these processes. Section 3 reviews emerging themes (ex., microenvironment, mechanotransduction, and immunomodulation), and Section 4 highlights new therapeutic approaches to overcome the unique challenges presented by the heterogeneous and metastatic tumor. This book is intended for undergraduates and postgraduates with an interest in the areas of medicine, oncology, and cancer biology as well as for the content expert searching for thorough reviews of current knowledge in these areas.

Reviews

“This book connects cancer metastasis, the major cause of death in patients with malignancy, with genomic instability. For oncologists and biologists.” (Pediatric Endocrinology Reviews (PER), Vol. 12 (4), 2015)


Table of contents (10 chapters)

  • Cancer Metastasis: Tracking and Attacking a Moving Target

    Rodenhiser, David I. (et al.)

    Pages 1-13

  • The Generation, Detection, and Prevention of Genomic Instability During Cancer Progression and Metastasis

    Chen, Helen (et al.)

    Pages 15-38

  • DNA Damage Response Pathways in Cancer Predisposition and Progression

    Ashour, Mohamed E. (et al.)

    Pages 39-74

  • Mathematical Modeling for DNA Repair, Carcinogenesis and Cancer Detection

    Tang, Jonathan (et al.)

    Pages 75-93

  • Animal Models of Metastasis

    Cochrane, Dawn R (et al.)

    Pages 95-123

Buy this book

eBook $129.00
price for USA (gross)
  • ISBN 978-3-319-12136-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA
  • ISBN 978-3-319-12135-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.99
price for USA
  • ISBN 978-3-319-35295-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Genomic Instability and Cancer Metastasis
Book Subtitle
Mechanisms, Emerging Themes, and Novel Therapeutic Strategies
Editors
  • Chris Maxwell
  • Cal Roskelley
Series Title
Cancer Metastasis - Biology and Treatment
Series Volume
20
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-12136-9
DOI
10.1007/978-3-319-12136-9
Hardcover ISBN
978-3-319-12135-2
Softcover ISBN
978-3-319-35295-4
Series ISSN
1568-2102
Edition Number
1
Number of Pages
X, 247
Number of Illustrations and Tables
1 b/w illustrations, 18 illustrations in colour
Topics