Resistance to Targeted Anti-Cancer Therapeutics

Resistance to Targeted ABC Transporters in Cancer

Editors: Efferth, Thomas (Ed.)

  • Provides up-to-date research on the role of ABC transporters in drug-resistant tumors
  • Examines the potential of radiopharmaceuticals for diagnosis of multidrug-resistant tumors and of nanotechnology to combat drug-resistant tumors
  • Features chapters which complement basic research with investigations from translational applications to oncology
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eBook $159.00
price for USA (gross)
  • ISBN 978-3-319-09801-2
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-3-319-09800-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-3-319-37996-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This critical review volume explores the theme of ABC transporters in the context of basic cancer research and its role in drug-resistant tumors. The chapters provided complement basic research by including investigations from translational applications to clinical oncology. The development of resistance is a major obstacle in cancer chemotherapy and the field has been moving rapidly in terms of determining the mechanisms for blocking ABC transporter-mediated drug efflux by specific inhibitors and thereby overcoming multidrug resistance. The volume covers these issues in careful detail. Additional topics include the relevance of ABC transporters in resistance to novel and established anticancer drugs and prognosis of patients to compounds, compounds used in photodynamic therapy, tyrosine kinase inhibitors and others. Furthermore, the potential of radiopharmaceuticals for diagnosis of multidrug-resistant tumors and of nanotechnology to combat drug-resistant tumors is also discussed.

About the authors

Thomas Efferth, Ph.D., is a full Professor and Chair of Pharmaceutical Biology at the University of Mainz in Germany. Dr. Efferth is an expert on ABC transporters and has given over 130 lectures at international conferences. Dr. Efferth has received over 6,000 citations in his career. In addition, Dr. Efferth is on the Editorial Board of 26 journals, including the International Journal of Oncology, Cancer Genomics and Proteomics, Current Medicinal Chemistry, Frontiers in Pharmacology, to name a few. He's also a scientific advisory board member of several institutions, including the German Pharmaceutical Society and the International Institute of Anticancer Research.

Table of contents (12 chapters)

  • Role of P-Glycoprotein for Resistance of Tumors to Anticancer Drugs: From Bench to Bedside

    Volm, Manfred (et al.)

    Pages 1-26

  • Clinical Relevance of Multidrug-Resistance-Proteins (MRPs) for Anticancer Drug Resistance and Prognosis

    Roundhill, E. A. (et al.)

    Pages 27-52

  • Role of Breast Cancer Resistance Protein (BCRP, ABCG2) in Cancer Outcomes and Drug Resistance

    Natarajan, Karthika (et al.)

    Pages 53-88

  • A New Strategy of ALA-Photodynamic Cancer Therapy: Inhibition of ABC Transporter ABCG2

    Ishikawa, Toshihisa (et al.)

    Pages 89-104

  • ATP Binding Cassette Transporters in Cancer Stem-Like Cells

    Perego, Paola

    Pages 105-131

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-3-319-09801-2
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-3-319-09800-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-3-319-37996-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Resistance to Targeted ABC Transporters in Cancer
Editors
  • Thomas Efferth
Series Title
Resistance to Targeted Anti-Cancer Therapeutics
Series Volume
4
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-09801-2
DOI
10.1007/978-3-319-09801-2
Hardcover ISBN
978-3-319-09800-5
Softcover ISBN
978-3-319-37996-8
Series ISSN
2196-5501
Edition Number
1
Number of Pages
X, 300
Number of Illustrations and Tables
39 b/w illustrations, 21 illustrations in colour
Topics