Springer Theses

Mathematical Modelling of Chromosome Replication and Replicative Stress

Authors: Karschau, Jens

  • Nominated as an outstanding Ph.D. thesis by the University of Aberdeen, UK
  • May contribute to resolving the random completion problem in biology
  • Comprehensive introduction on DNA replication as well as DNA replication modelling suitable also for non-biologists
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eBook $99.00
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  • ISBN 978-3-319-08861-7
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  • Immediate eBook download after purchase
Hardcover $129.00
price for USA
  • ISBN 978-3-319-08860-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $129.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: October 27, 2016
  • ISBN 978-3-319-36282-3
  • Free shipping for individuals worldwide
Rent the ebook  
  • Rental duration: 1 or 6 month
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About this book

DNA replication is arguably the most crucial process at work in living cells. It is the mechanism by which organisms pass their genetic information from one generation to the next and life on Earth would be unthinkable without it. Despite the discovery of DNA structure in the 1950s, the mechanism of its replication remains rather elusive.

This work makes important contributions to this line of research. In particular, it addresses two key questions in the area of DNA replication: which evolutionary forces drive the positioning of replication origins in the chromosome and how is the spatial organization of replication factories achieved inside the nucleus of a cell?.

A cross-disciplinary approach uniting physics and biology is at the heart of this research. Along with experimental support, statistical physics theory produces optimal origin positions and provides a model for replication fork assembly in yeast. Advances made here can potentially further our understanding of disease mechanisms such as the abnormal replication in cancer.

Table of contents (4 chapters)

  • Introduction

    Karschau, Jens

    Pages 1-18

  • Optimal Origin Placement for Minimal Replication Time

    Karschau, Jens

    Pages 19-48

  • Actively Replicating Domains Randomly Associate into Replication Factories

    Karschau, Jens

    Pages 49-74

  • Summary and Conclusions

    Karschau, Jens

    Pages 75-76

Buy this book

eBook $99.00
price for USA (gross)
  • ISBN 978-3-319-08861-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $129.00
price for USA
  • ISBN 978-3-319-08860-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $129.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: October 27, 2016
  • ISBN 978-3-319-36282-3
  • Free shipping for individuals worldwide
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Mathematical Modelling of Chromosome Replication and Replicative Stress
Authors
Series Title
Springer Theses
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-08861-7
DOI
10.1007/978-3-319-08861-7
Hardcover ISBN
978-3-319-08860-0
Softcover ISBN
978-3-319-36282-3
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XIII, 76
Number of Illustrations and Tables
48 b/w illustrations, 9 illustrations in colour
Topics