ADAMTS13

Biology and Disease

Editors: Rodgers, George M. (Ed.)

  • An up-to-date comprehensive overview of ADAMTS-13 basic science, including less-recognized aspects of the protein
  • Covers ADAMTS-13's role in disease, including its potential as a therapeutic agent
  • One of the only books to focus on this specific protein, it fills a gap in the literature and its coverage of both scientific and clinical aspects make it relevant both to researchers and clinicians
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Buy this book

eBook $119.00
price for USA (gross)
  • ISBN 978-3-319-08717-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.00
price for USA
  • ISBN 978-3-319-08716-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $159.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: December 15, 2016
  • ISBN 978-3-319-34730-1
  • Free shipping for individuals worldwide
About this book

This comprehensive volume discusses the protease ADAMTS13, summarizing the current status of basic and clinical research. The nine authoritative chapters begin with a historical perspective followed by exploration of the biochemistry and structure-function relationships of ADAMTS13 as well as its normal function in hemostasis (cleavage of von Willebrand factor). Emerging research themes for ADAMTS13 are covered, including its potential role in angiogenesis and other aspects of cell biology. Additional topics include laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and acquired ADAMTS13 deficiency. A chapter on related thrombotic microangiopathic (TMA) disorders examines the differences between TMAs associated with ADAMTS13 deficiency and those not associated with ADAMTS13 deficiency. A final chapter reviews the preliminary information on emerging aspects of ADAMTS13, such as the status of recombinant ADAMTS13 products and their potential utility.

 

Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and Disease is a significant resource for clinical hematologists, transfusion medicine physicians, and researchers interested in hemostasis, vascular biology, biochemistry, and metalloproteases.

About the authors

Dr. George M. Rodgers received his M.D. and Ph.D. in Pharmacology from Tulane University Medical School in New Orleans, Louisiana. He completed his internal medicine training at Baylor College of Medicine in Houston, Texas, along with a hematology fellowship at the University of California, San Francisco, and served on the UCSF faculty. He is currently Professor of Medicine and Pathology at the University of Utah Medical Center in Salt Lake City and Medical Director of the Coagulation Laboratory at ARUP Laboratories. Dr. Rodgers is board certified in internal medicine, hematology and hematopathology. His clinical interests are in benign hematology, particularly coagulation disorders, and his basic research interests are in vascular biology, especially endothelial cell regulation of hemostasis. A current project is studying the role of ADAMTS13 in angiogenesis.

Reviews

“The purpose is to provide a current overview of ADAMTS13, spanning basic science and clinical medicine. … of interest to any medical students, residents, practicing physicians, or allied health practitioners involved in the care of these patients. … If you are even remotely interested in ADAMTS13, you must get this book. This is most certainly one of the best current reviews of this subject available today.” (Valerie L. Ng, Doody’s Book Reviews, November, 2015)


Table of contents (9 chapters)

  • History of Thrombotic Thrombocytopenic Purpura and the von Willebrand Factor–Cleaving Protease, ADAMTS13

    Lämmle, Bernhard (et al.)

    Pages 1-19

  • Overview of the ADAMTS Superfamily

    Apte, Suneel S.

    Pages 21-37

  • ADAMTS13: Structure and Function

    Zheng, X. Long

    Pages 39-57

  • ADAMTS13 and Angiogenesis

    Lee, Manfai (et al.)

    Pages 59-72

  • Hereditary Deficiency of ADAMTS13 Activity: Upshaw–Schulman Syndrome

    Fujimura, Yoshihiro (et al.)

    Pages 73-90

Buy this book

eBook $119.00
price for USA (gross)
  • ISBN 978-3-319-08717-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.00
price for USA
  • ISBN 978-3-319-08716-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $159.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: December 15, 2016
  • ISBN 978-3-319-34730-1
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
ADAMTS13
Book Subtitle
Biology and Disease
Editors
  • George M. Rodgers
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-08717-7
DOI
10.1007/978-3-319-08717-7
Hardcover ISBN
978-3-319-08716-0
Softcover ISBN
978-3-319-34730-1
Edition Number
1
Number of Pages
X, 186
Number of Illustrations and Tables
9 b/w illustrations, 24 illustrations in colour
Topics