Springer Theses

NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens

A Novel NMR-Tool for Natural Product Detection

Authors: Stein, Martin Lorenz

  • Nominated as an Outstanding Ph.D. thesis by TU München, Germany
  • Highlights a new approach to access undisclosed natural products
  • Describes biological dimensions of proteasome inhibitors
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eBook $99.00
price for USA (gross)
  • ISBN 978-3-319-07914-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $129.00
price for USA
  • ISBN 978-3-319-07913-4
  • Free shipping for individuals worldwide
  • Online orders shipping within 2-3 days.
Softcover $129.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 4, 2016
  • ISBN 978-3-319-38399-6
  • Free shipping for individuals worldwide
About this book

Martin Stein's thesis describes a novel methodology for natural product discovery. Due to its high degree of reproducibility, robustness and sensitivity, the technique can be utilized to detect even trace amounts of bioactive substances in heterogeneous matrices such as fermentation broths or crude organic extracts. This research is thus relevant for a large number of researchers working in natural product discovery. Applications of this novel NMR-based approach include suitable environmental triggers for the induction of biosynthetic machineries. The author demonstrates the extraordinary value of this approach by the successful isolation of two potent inhibitors of the pharmaceutically relevant proteasome core particle from the insect pathogen photorhabdus luminescens. This thesis has led to a number of publications in high-impact journals.

Buy this book

eBook $99.00
price for USA (gross)
  • ISBN 978-3-319-07914-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $129.00
price for USA
  • ISBN 978-3-319-07913-4
  • Free shipping for individuals worldwide
  • Online orders shipping within 2-3 days.
Softcover $129.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 4, 2016
  • ISBN 978-3-319-38399-6
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens
Book Subtitle
A Novel NMR-Tool for Natural Product Detection
Authors
Series Title
Springer Theses
Copyright
2014
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-07914-1
DOI
10.1007/978-3-319-07914-1
Hardcover ISBN
978-3-319-07913-4
Softcover ISBN
978-3-319-38399-6
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XVI, 71
Number of Illustrations and Tables
4 b/w illustrations, 24 illustrations in colour
Topics