SpringerBriefs in Neuroscience

The UNC-53-mediated Interactome

Analysis of its Role in the Generation of the C. elegans Connectome

Authors: Pandey, Amita, Pandey, Girdhar K.

  • The book presents C. elegans as model organism for the development of the nervous system translation
  • Discusses various disorders that are associated with improper wiring of the nervous system
  • Gives an overview on various interactomes involved in DV and AP guidance, their mechanism of action, subcellular localization and functional role
see more benefits

Buy this book

eBook $39.99
price for USA (gross)
  • ISBN 978-3-319-07827-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $54.99
price for USA
  • ISBN 978-3-319-07826-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book gives an overview of various interactomes involved in dorsal ventral (DV) and anterior posterior (AP) guidance, their mechanisms of action, subcellular localizations, and functional roles. It will provide readers a better understanding of the development of the nervous system, which in turn will help to find cures to various neural and other disorders.​

In nematodes there are two types of guidance systems, including DV and AP guidance. The signaling process that guides the growth cones along the DV axis has remained intact in both vertebrates and invertebrates. The adaptor protein UNC-53 appears to play a part in migration along the AP axis in both worms and their human homologs. “Neuron Navigators” (NAV) are also involved in nervous system development 

Table of contents (5 chapters)

  • Introduction

    Pandey, Amita (et al.)

    Pages 1-7

  • Guidance Molecules Required for Growth Cone Migration of Cells and Axons

    Pandey, Amita (et al.)

    Pages 9-30

  • Regulatory Mechanisms of Guidance Molecules During Growth Cone Migration and Axon Outgrowth

    Pandey, Amita (et al.)

    Pages 31-46

  • Signaling Pathways Downstream of the Guidance Cues and Receptors

    Pandey, Amita (et al.)

    Pages 47-71

  • Functional Characterization of UNC-53, a Scaffolding Protein During Axon Outgrowth and Cell Migration

    Pandey, Amita (et al.)

    Pages 73-87

Buy this book

eBook $39.99
price for USA (gross)
  • ISBN 978-3-319-07827-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $54.99
price for USA
  • ISBN 978-3-319-07826-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
The UNC-53-mediated Interactome
Book Subtitle
Analysis of its Role in the Generation of the C. elegans Connectome
Authors
Series Title
SpringerBriefs in Neuroscience
Copyright
2014
Publisher
Springer International Publishing
Copyright Holder
The Author(s)
eBook ISBN
978-3-319-07827-4
DOI
10.1007/978-3-319-07827-4
Softcover ISBN
978-3-319-07826-7
Series ISSN
2191-558X
Edition Number
1
Number of Pages
VI, 87
Number of Illustrations and Tables
1 b/w illustrations, 14 illustrations in colour
Topics