Springer Theses

Modelling the Short QT Syndrome Gene Mutations

And Their Role in Cardiac Arrhythmogenesis

Authors: Adeniran, Ismail

  • Nominated as an outstanding Ph. D. thesis by the University of Manchester, UK
  • Presents multiphysics modelling of the human heart from ion channel to cell to whole organ
  • Provides a functional analysis of the impact of gene mutations on cardiac arrhythmogenesis
  • Comprehensive detail of predictive physiology
see more benefits

Buy this book

eBook $139.00
price for USA (gross)
  • ISBN 978-3-319-07200-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.00
price for USA
  • ISBN 978-3-319-07199-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: October 27, 2016
  • ISBN 978-3-319-36151-2
  • Free shipping for individuals worldwide
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
About this book

The Short QT Syndrome (SQTS) is characterized by abbreviated QT intervals on the electrocardiogram, increased risk of cardiac arrhythmias and sudden death. Although several gene mutations have been identified in SQT patients, the role of these mutations in promoting arrhythmogenesis is still not completely understood. Consequently, this thesis employs multidisciplinary approaches to develop a 3D virtual heart, which is then used to elucidate how the short QT syndrome facilitates and maintains ventricular arrhythmias and to determine its effects on ventricular mechanical contraction. The findings in this thesis provide a comprehensive and mechanistic explanation for a number of gene mutations associated with potassium channels in terms of susceptibility to arrhythmia. The multiphysics models developed provide a powerful platform for identifying the root causes of various arrhythmias and investigating therapeutic interventions for these diseases.

The thesis was examined by Prof. Chris Huang of the University of Cambridge, the most authoritative figure in cardiac electrophysiology, who has described the work as “outstanding.”

Table of contents (10 chapters)

  • Introduction to Ion Channels and the Cardiac Action Potential

    Adeniran, Ismail

    Pages 1-31

  • Potassium Channels Implicated in the Short QT Syndrome

    Adeniran, Ismail

    Pages 33-49

  • The Short QT Syndrome

    Adeniran, Ismail

    Pages 51-64

  • Model Development

    Adeniran, Ismail

    Pages 65-84

  • Methods, Experimental Protocols and Mathematical Preliminaries

    Adeniran, Ismail

    Pages 85-100

Buy this book

eBook $139.00
price for USA (gross)
  • ISBN 978-3-319-07200-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.00
price for USA
  • ISBN 978-3-319-07199-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: October 27, 2016
  • ISBN 978-3-319-36151-2
  • Free shipping for individuals worldwide
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Modelling the Short QT Syndrome Gene Mutations
Book Subtitle
And Their Role in Cardiac Arrhythmogenesis
Authors
Series Title
Springer Theses
Copyright
2014
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-07200-5
DOI
10.1007/978-3-319-07200-5
Hardcover ISBN
978-3-319-07199-2
Softcover ISBN
978-3-319-36151-2
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XVII, 217
Number of Illustrations and Tables
64 b/w illustrations, 38 illustrations in colour
Topics