Overview
- Nominated as an outstanding Ph. D. thesis by the University of Manchester, UK
- Presents multiphysics modelling of the human heart from ion channel to cell to whole organ
- Provides a functional analysis of the impact of gene mutations on cardiac arrhythmogenesis
- Comprehensive detail of predictive physiology
- Includes supplementary material: sn.pub/extras
Part of the book series: Springer Theses (Springer Theses)
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Table of contents (10 chapters)
Keywords
- 3D Virtual Heart
- Arrhythmia Simulation with Virtual Heart
- Gene Mutations Inducing Heart Arrhythmia
- Human Ventricles
- Markov Models
- Multiphysics Models of Heart Arrhythmia
- Potassium Channels and Heart Arrhythmia
- Short QT Syndrome
- Stretch-activated Channel
- Ventricular Arryhthmias
- Ventricular Fibrillation
- systems biology
About this book
The Short QT Syndrome (SQTS) is characterized by abbreviated QT intervals on the electrocardiogram, increased risk of cardiac arrhythmias and sudden death. Although several gene mutations have been identified in SQT patients, the role of these mutations in promoting arrhythmogenesis is still not completely understood. Consequently, this thesis employs multidisciplinary approaches to develop a 3D virtual heart, which is then used to elucidate how the short QT syndrome facilitates and maintains ventricular arrhythmias and to determine its effects on ventricular mechanical contraction. The findings in this thesis provide a comprehensive and mechanistic explanation for a number of gene mutations associated with potassium channels in terms of susceptibility to arrhythmia. The multiphysics models developed provide a powerful platform for identifying the root causes of various arrhythmias and investigating therapeutic interventions for these diseases.
The thesis was examined by Prof. Chris Huang of the University of Cambridge, the most authoritative figure in cardiac electrophysiology, who has described the work as “outstanding.”
Authors and Affiliations
Bibliographic Information
Book Title: Modelling the Short QT Syndrome Gene Mutations
Book Subtitle: And Their Role in Cardiac Arrhythmogenesis
Authors: Ismail Adeniran
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-3-319-07200-5
Publisher: Springer Cham
eBook Packages: Physics and Astronomy, Physics and Astronomy (R0)
Copyright Information: Springer International Publishing Switzerland 2014
Hardcover ISBN: 978-3-319-07199-2Published: 01 July 2014
Softcover ISBN: 978-3-319-36151-2Published: 10 September 2016
eBook ISBN: 978-3-319-07200-5Published: 11 June 2014
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: XVII, 217
Number of Illustrations: 64 b/w illustrations, 38 illustrations in colour
Topics: Systems Biology, Membrane Biology, Complex Systems, Cardiology, Numerical and Computational Physics, Simulation, Statistical Physics and Dynamical Systems