Springer Theses

Dissecting Regulatory Interactions of RNA and Protein

Combining Computation and High-throughput Experiments in Systems Biology

Authors: Jens, Marvin

  • Nominated as an outstanding PhD thesis by Max Delbrueck Center for Molecular Medicine, Germany
  • Combines concepts and approaches from physics with high-throughput data to model gene regulation and answer biological questions
  • Offers theoretical, computational and biological contributions to the study of the transcriptome
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  • ISBN 978-3-319-07082-7
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Hardcover $129.00
price for USA
  • ISBN 978-3-319-07081-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $129.00
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  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: October 28, 2016
  • ISBN 978-3-319-36117-8
  • Free shipping for individuals worldwide
Rent the ebook  
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About this book

The work described in this book is an excellent example of interdisciplinary research in systems biology. It shows how concepts and approaches from the field of physics can be efficiently used to answer biological questions and reports on a novel methodology involving creative computer-based analyses of high-throughput biological data. Many of the findings described in the book, which are the result of collaborations between the author (a theoretical scientist) and experimental biologists and between different laboratories, have been published in high-quality peer-reviewed journals such as Molecular Cell and Nature. However, while those publications address different aspects of post-transcriptional gene regulation, this book provides readers with a complete, coherent and logical view of the research project as a whole. The introduction presents post-transcriptional gene regulation from a distinct angle, highlighting aspects of information theory and evolution and laying the groundwork for the questions addressed in the subsequent chapters, which concern the regulation of the transcriptome as the primary functional carrier of active genetic information.

Table of contents (7 chapters)

  • Introduction

    Jens, Marvin

    Pages 1-19

  • Computational Analysis of PAR-CLIP Data

    Jens, Marvin

    Pages 21-33

  • Transcriptome-Wide Analysis of Regulatory Interactions of the RNA-Binding Protein HuR

    Jens, Marvin

    Pages 35-54

  • Binding Site Occupancy with Competition Interactions in Equilibrium

    Jens, Marvin

    Pages 55-67

  • Circular RNAs Are a Large Class of Animal RNAs with Regulatory Potency

    Jens, Marvin

    Pages 69-80

Buy this book

eBook $99.00
price for USA (gross)
  • ISBN 978-3-319-07082-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $129.00
price for USA
  • ISBN 978-3-319-07081-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $129.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: October 28, 2016
  • ISBN 978-3-319-36117-8
  • Free shipping for individuals worldwide
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Dissecting Regulatory Interactions of RNA and Protein
Book Subtitle
Combining Computation and High-throughput Experiments in Systems Biology
Authors
Series Title
Springer Theses
Copyright
2014
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-07082-7
DOI
10.1007/978-3-319-07082-7
Hardcover ISBN
978-3-319-07081-0
Softcover ISBN
978-3-319-36117-8
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XVIII, 99
Number of Illustrations and Tables
19 b/w illustrations, 19 illustrations in colour
Topics