Resistance to Targeted Anti-Cancer Therapeutics

Resistance to Proteasome Inhibitors in Cancer

Molecular Mechanisms and Strategies to Overcome Resistance

Editors: Dou, Q. Ping (Ed.)

  • Reveals latest discoveries related to the molecular mechanisms of proteasome inhibitor resistance
  • Discusses proteasome inhibitor resistance in multiple contexts, including multiple myeloma, leukemia, mantle cell lymphoma, melanoma and other cancers
  • Explores multiple, cutting-edge strategies to overcome resistance
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eBook $159.00
price for USA (gross)
  • ISBN 978-3-319-06752-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-3-319-06751-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: August 30, 2016
  • ISBN 978-3-319-37703-2
  • Free shipping for individuals worldwide
About this book

The book explores cutting-edge strategies to overcome proteasome inhibitor resistance, including the second generation 20S proteasome inhibitors, novel combinational therapies, and new targets in the ubiquitin-proteasome pathway (e.g., ubiquitin E3 ligases, deubiquitinases, 19S proteasomal ATPases, histone deacetylases, oxidative stress and proteotoxic stress pathways and pharmacogenomic signature profiling) in resistant cancer cells. The mechanisms of action and resistance of proteasome inhibitors, such as bortezomib and carfilzomib in human cancers, including multiple myeloma, mantle cell lymphoma, acute leukemia, and solid tumors are explored in depth in this volume.

This timely volume unveils the most current discoveries of the mechanisms behind proteasome inhibitor resistance, which will help illuminate the future of cancer therapies.

About the authors

Q. Ping Dou, Ph.D. is Professor of Pathology, Cancer Biology and Pharmacology at Wayne State University School of Medicine. Dr. Dou's laboratory is one of the first to report that proteasome inhibitors rapidly induce tumor cell apoptosis, selectively activate the cell death program in oncogene-transformed, but not normal or untransformed cells and are able to trigger apoptotic death in human cancer cells that are resistant to various anticancer agents. He also serves on multiple editorial boards, including The Open Leukemia Journal, Journal of Clinical Oncology, Frontiers of Bioscience, to name a few.

Table of contents (15 chapters)

  • Proteasome Inhibitors and Lessons Learned from Their Mechanisms of Action and Resistance in Human Cancer

    Schmitt, Sara M. (et al.)

    Pages 1-46

  • Resistance to Proteasome Inhibitors in Multiple Myeloma

    Cottini, Francesca (et al.)

    Pages 47-80

  • Overcoming Bortezomib Resistance: A Review of the Second-Generation Proteasome Inhibitor Carfilzomib in the Treatment of Multiple Myeloma

    Lee, Hans C. (et al.)

    Pages 81-98

  • Proteasome Inhibitors in the Treatment of Multiple Myeloma and AL Amyloidosis

    Zonder, Jeffrey A.

    Pages 99-115

  • Profiling Bortezomib Resistance in Multiple Myeloma: Implications in Personalized Pharmacotherapy

    Mitra, Amit Kumar (et al.)

    Pages 117-147

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-3-319-06752-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-3-319-06751-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: August 30, 2016
  • ISBN 978-3-319-37703-2
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Resistance to Proteasome Inhibitors in Cancer
Book Subtitle
Molecular Mechanisms and Strategies to Overcome Resistance
Editors
  • Q. Ping Dou
Series Title
Resistance to Targeted Anti-Cancer Therapeutics
Copyright
2014
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-06752-0
DOI
10.1007/978-3-319-06752-0
Hardcover ISBN
978-3-319-06751-3
Softcover ISBN
978-3-319-37703-2
Series ISSN
2196-5501
Edition Number
1
Number of Pages
XI, 390
Number of Illustrations and Tables
4 b/w illustrations, 51 illustrations in colour
Topics