Springer Theses

Peptide and Protein Interaction with Membrane Systems

Applications to Antimicrobial Therapy and Protein Drug Delivery

Authors: Bobone, Sara

  • Nominated as an outstanding Ph.D. thesis by the University of Rome Tor Vergata, Italy
  • Selected as the as the best Italian Ph.D. Physical Chemistry Thesis 2012-2013 by the Italian Chemical Society
  • Provides a comprehensive but accessible introduction to both antimicrobial peptides and protein-based drugs: two hot areas in biomolecular pharmaceutics
  • Presents numerous examples of the use of fluorescence spectroscopy to characterize peptide and protein interaction with lipid membranes, which provide a good starting point for the novice in this field
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eBook $99.00
price for USA (gross)
  • ISBN 978-3-319-06434-5
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  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $129.00
price for USA
  • ISBN 978-3-319-06433-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $129.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 3, 2016
  • ISBN 978-3-319-38273-9
  • Free shipping for individuals worldwide
About this book

In her thesis, Sara Bobone outlines spectroscopic studies of antimicrobial peptides (AMPs) which are promising lead compounds for drugs used to fight multidrug resistant bacteria. Bobone shows that AMPs interact with liposomes and she clarifies the structure of pores formed by one of these molecules. These results help us to understand how AMPs are selective for bacterial membranes and how their activity can be finely tuned by modifying their sequence. Findings which solve several conundrums debated in the literature for years. In addition, Bobone uses liposomes as nanotemplates for the photopolymerization of hydrogels - exploiting the self- assembly properties of phospholipids. Bobone was able to trap an enzyme using nanometeric particles, while still allowing its activity by the diffusion of substrates and products through the network of the polymer. The innovative nano devices described in this thesis could solve many of the hurdles still hampering the therapeutic application of protein-based drugs.

About the authors

I received my M.Sc. Degree in Chemistry magna cum laude from the University of Rome "Sapienza". After the degree, I moved to Tor Vergata, where I won a fellowship for PhD students in Chemical Sciences, under the supervision of Prof. L. Stella. I defended my thesis in 2013 and then continued my work as a postdoctoral fellow. The thesis was awarded the 2012-2013 "Premio Semerano" by the Italian Chemical Society, as the best Italian PhD Physical Chemistry Thesis. The thesis work led to the publication of 7 papers on international journals and to the participation to 13 international and national conferences.

Table of contents (7 chapters)

Buy this book

eBook $99.00
price for USA (gross)
  • ISBN 978-3-319-06434-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $129.00
price for USA
  • ISBN 978-3-319-06433-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $129.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 3, 2016
  • ISBN 978-3-319-38273-9
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Peptide and Protein Interaction with Membrane Systems
Book Subtitle
Applications to Antimicrobial Therapy and Protein Drug Delivery
Authors
Series Title
Springer Theses
Copyright
2014
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-06434-5
DOI
10.1007/978-3-319-06434-5
Hardcover ISBN
978-3-319-06433-8
Softcover ISBN
978-3-319-38273-9
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XIII, 140
Number of Illustrations and Tables
76 b/w illustrations, 18 illustrations in colour
Topics