Current Topics in Microbiology and Immunology

Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases

Editors: Oldstone, Michael B. A., Rosen, Hugh (Eds.)

  • Written by leading experts in the field
  • Provides a comprehensive and up to date overview on sphingosine-1-phosphate signaling
  • An invaluable source of information for both basic and clinical researchers
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eBook $149.00
price for USA (gross)
  • ISBN 978-3-319-05879-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-3-319-05878-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: October 7, 2016
  • ISBN 978-3-319-37603-5
  • Free shipping for individuals worldwide
About this book

This volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters define the pathways to understand S1P signaling. They cover the organization of signaling systems, the structural biology of the S1P1 receptor, and the chemical and genetic tools that are available and useful to explore this area of research and therapeutics. The later chapters highlight S1P and endothelial integrity, lymphocyte migration in the spleen, and S1P agonist in controlling immunopathologic manifestations of acute respiratory influenza virus infection (in the lung), and its accompanying cytokine storm as well as immunopathologic disease of the central nervous system, including the beginning of treatments in multiple sclerosis. One chapter reveals the possible involvement of other lipid molecules, their use for better understanding lipid signaling, and their potential in the modulation of immune responses.

About the authors

Michael B.A. Oldstone has been a successful series editor, volume editor and author of Current Topics in Microbiology and Immunology for several decades. He is a professor based at The Scripps Research Institute, La Jolla, CA, and a member of the National Academy of Sciences. Hugh Rosen is a professor at The Scripps Research Institute, La Jolla, CA, USA.

Table of contents (8 chapters)

  • The Organization of the Sphingosine 1-Phosphate Signaling System

    Rosen, Hugh (et al.)

    Pages 1-21

  • Structural Biology of the S1P1 Receptor

    Hanson, Michael A. (et al.)

    Pages 23-53

  • Chemical and Genetic Tools to Explore S1P Biology

    Cahalan, Stuart M.

    Pages 55-83

  • S1P Control of Endothelial Integrity

    Xiong, Yuquan (et al.)

    Pages 85-105

  • Blood, Sphingosine-1-Phosphate and Lymphocyte Migration Dynamics in the Spleen

    Arnon, Tal I. (et al.)

    Pages 107-128

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-3-319-05879-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-3-319-05878-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: October 7, 2016
  • ISBN 978-3-319-37603-5
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases
Editors
  • Michael B. A. Oldstone
  • Hugh Rosen
Series Title
Current Topics in Microbiology and Immunology
Series Volume
378
Copyright
2014
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-05879-5
DOI
10.1007/978-3-319-05879-5
Hardcover ISBN
978-3-319-05878-8
Softcover ISBN
978-3-319-37603-5
Series ISSN
0070-217X
Edition Number
1
Number of Pages
VII, 184
Number of Illustrations and Tables
5 b/w illustrations, 22 illustrations in colour
Topics