Overview
- Editors:
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Fazlul H. Sarkar
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Pathology, Wayne State University School of Medicine, Detroit, USA
Unique book focusing on microRNA targeted therapy for a variety of solid tumors
First book which documents systems biology and network modeling of miRNAs for cancer therapy
The chapters in this book is supplemented by informative illustrations, colorful diagrams and tables
Extensive lists of references in every chapters represents state of our knowledge in miRNAs as novel targets for cancer therapy
Serves as a practical guide for scientists of all levels of study
Includes supplementary material: sn.pub/extras
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Table of contents (18 chapters)
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- Sanila H. Sarkar, Aamir Ahmad, Sandeep Mittal
Pages 1-27
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- Chaya Brodie, Efrat Buchris, Hae Kyung Lee
Pages 29-49
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- Zhaohui Gong, Zhuo Dong, Lihua Yang, Jie Yang, Jingqiu Li, Yanping Le et al.
Pages 51-82
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- Yu Fujita, Kazuyoshi Kuwano, Takahiro Ochiya
Pages 83-98
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- Aamir Ahmad, Kevin R. Ginnebaugh, Yiwei Li, Bin Bao, Shirish M. Gadgeel, Fazlul H. Sarkar
Pages 99-114
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- Rong Guo, Cheryl Sherman-Baust, Kotb Abdelmohsen
Pages 115-127
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- Kouji Banno, Miho Iida, Megumi Yanokura, Iori Kisu, Kanako Nakamura, Masataka Adachi et al.
Pages 129-137
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- Yingjie Yu, Pratima Nangia-Makker, Adhip P. N. Majumdar
Pages 139-155
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- Jens U. Marquardt, Peter R. Galle
Pages 157-174
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- Shahana Majid, Rajvir Dahiya
Pages 175-188
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- Marion Gayral, Yannick Delpu, Jérôme Torrisani, Pierre Cordelier
Pages 189-197
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- Yiwei Li, Dejuan Kong, Aamir Ahmad, Bin Bao, Fazlul H. Sarkar
Pages 199-217
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- Cesar Seigi Fuziwara, Edna Teruko Kimura
Pages 219-237
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- Josep Roma, Ana Almazán-Moga, José Sánchez de Toledo, Soledad Gallego, Miguel F. Segura
Pages 239-263
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- Hong YuWH, Daniel SzeMY, William ChoCS, YipSP
Pages 265-287
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- Ammad Ahmad Farooqi, Ilhan Yaylim
Pages 309-325
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- Ramzi M. Mohammad, B. Bao, Fazlul H. Sarkar, Philip A. Philip, Asfar S. Azmi
Pages 327-337
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Back Matter
Pages 339-351
About this book
Since the discovery of microRNAs (miRNAs) some twenty years ago by Victor Ambros, David Baulcombe and Gary Ruvkun, these three scientists worked to uncover the mystery of miRNA, the small segments of nucleotides that silence genes. While studying the development of the nematode worm, Ambros and Ruvkun discovered miRNA in animals, while Baulcombe discovered it in plants. Since their discovery, it took more than two decade to fully appreciate the value of miRNA in human health and diseases. Emerging evidence suggest that the activation of oncogenes and/or the inactivation of tumor suppressor genes contribute to the development and progression of tumors. The regulation of genes is by far controlled by many transcription factors which are often deregulated during the development and progression of cancer. In addition, emerging evidence clearly suggests that the deregulation of miRNAs or small non-coding RNAs could also regulate the expression of genes and likewise, miRNA genes are also regulated by transcription factors. The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs) and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass. Therefore, miRNA targeted therapy is an attractive attribute of miRNA research, which is covered through eighteen chapters complied in this book “MicroRNA targeted Cancer therapy” and it is hoped that the field of miRNA research will be appreciated through critical reading of these chapters on the cutting-edge research on miRNAs.
Editors and Affiliations
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Pathology, Wayne State University School of Medicine, Detroit, USA
Fazlul H. Sarkar
