MicroRNA Targeted Cancer Therapy

Editors: Sarkar, Fazlul H. (Ed.)

  • Unique book focusing on microRNA targeted therapy for a variety of solid tumors
  • First book which documents systems biology and network modeling of miRNAs for cancer therapy
  • The chapters in this book is supplemented by informative illustrations, colorful diagrams and tables
  • Extensive lists of references in every chapters represents state of our knowledge in miRNAs as novel targets for cancer therapy
  • Serves as a practical guide for scientists of all levels of study
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Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-3-319-05134-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-3-319-05133-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-3-319-37606-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Since the discovery of microRNAs (miRNAs) some twenty years ago by Victor Ambros, David Baulcombe and Gary Ruvkun, these three scientists worked to uncover the mystery of miRNA, the small segments of nucleotides that silence genes. While studying the development of the nematode worm, Ambros and Ruvkun discovered miRNA in animals, while Baulcombe discovered it in plants. Since their discovery, it took more than two decade to fully appreciate the value of miRNA in human health and diseases. Emerging evidence suggest that the activation of oncogenes and/or the inactivation of tumor suppressor genes contribute to the development and progression of tumors. The regulation of genes is by far controlled by many transcription factors which are often deregulated during the development and progression of cancer. In addition, emerging evidence clearly suggests that the deregulation of miRNAs or small non-coding RNAs could also regulate the expression of genes and likewise, miRNA genes are also regulated by transcription factors. The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs) and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass. Therefore, miRNA targeted therapy is an attractive attribute of miRNA research, which is covered through eighteen chapters complied in this book “MicroRNA targeted Cancer therapy” and it is hoped that the field of miRNA research will be appreciated through critical reading of these chapters on the cutting-edge research on miRNAs.

Table of contents (18 chapters)

  • The Therapeutic Role of MicroRNAs in Human Gliomas

    Sarkar, Sanila H. (et al.)

    Pages 1-27

  • miRNA Expression and Functions in Glioma and Glioma Stem Cells

    Brodie, Chaya (et al.)

    Pages 29-49

  • The Role of MicroRNA in Lung Cancer Drug Resistance and Targeted Therapy

    Gong, Zhaohui (et al.)

    Pages 51-82

  • The Potential Role of MicroRNA-Based Therapy for Lung Cancer Stem Cells

    Fujita, Yu (et al.)

    Pages 83-98

  • miRNA Targeted Therapy in Lung Cancer

    Ahmad, Aamir (et al.)

    Pages 99-114

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-3-319-05134-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-3-319-05133-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-3-319-37606-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
MicroRNA Targeted Cancer Therapy
Editors
  • Fazlul H. Sarkar
Copyright
2014
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-05134-5
DOI
10.1007/978-3-319-05134-5
Hardcover ISBN
978-3-319-05133-8
Softcover ISBN
978-3-319-37606-6
Edition Number
1
Number of Pages
X, 351
Number of Illustrations and Tables
3 b/w illustrations, 25 illustrations in colour
Topics