SpringerBriefs in Cancer Research

SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

Authors: Inuzuka, Hiroyuki, Wei, Wenyi

  • Includes updated profiles of SCF and APC cellular functions and their characterized ubiquitin substrates
  • Introduces the emergent SCF family members in the human genome and summarizes phenotypes in which the adapter proteins of SCF and APC are manipulated to reflect the pathogenesis of human cancer
  • Discusses how SCF and APC may represent promising therapeutic targets to treat various types of cancers
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eBook $39.99
price for USA (gross)
  • ISBN 978-3-319-05026-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $54.99
price for USA
  • ISBN 978-3-319-05025-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This SpringerBrief explores the physiological roles of Skp1-Cullin1-F-box Complex (SCF) and Anaphase Promoting Complex (APC) in normal cells and in tumor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to be the major driving forces governing proper cell cycle progression. Defective cell cycle regulation leads to genomic instability and ultimately, cancer development. Selective degradation of key cell cycle regulators by the ubiquitin-proteasome system has been proven to be a major regulatory mechanism for ensuring ordered and coordinated cell cycle progression. The SCF and APC E3 ligases have been characterized to play pivotal roles in regulating the cell cycle progression by timely degrading various critical cell cycle regulators. This Brief reviews recent studies that have shown that deregulation of signaling pathways in which the two ubiquitin ligases are involved causes aberrant cell cycle regulation, in turn leading to tumorigenesis. The text also discusses how SCF and APC may present promising therapeutic targets to treat various cancers.

About the authors

Wenyi Wei, Ph.D, is Associate Professor of Pathology at Beth Israel Deaconess Medical Center, Harvard Medical School. Dr. Wei is an expert in the mE3 ubiquitin ligase complexes. He's on the editorial board of several journals including American Journal of Cancer Research, Molecular and Cellular Biology, Cancer Hallmarks, Cancer Research, and Journal of Biological Chemistry. He has published 47 scientific papers, which have received over 2,740 citations. Hiroyuki Inuzuka, Ph.D is Assistant Professor of Pathology at Beth Israel Deaconess Medical Center, Harvard Medical School.

Table of contents (6 chapters)

  • Introduction

    Liu, Pengda (et al.)

    Pages 1-13

  • The Role of FBXW Subfamily of F-box Proteins in Tumorigenesis

    Lau, Alan W. (et al.)

    Pages 15-45

  • The Role of FBXL Subfamily of F-box Proteins in Tumorigenesis

    North, Brian J. (et al.)

    Pages 47-71

  • The Role of FBXO Subfamily of F-box Proteins in Tumorigenesis

    Guo, Jianping (et al.)

    Pages 73-87

  • The Role of APC E3 Ubiquitin Ligase Complex in Tumorigenesis

    Zhang, Jinfang (et al.)

    Pages 89-111

Buy this book

eBook $39.99
price for USA (gross)
  • ISBN 978-3-319-05026-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $54.99
price for USA
  • ISBN 978-3-319-05025-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
SCF and APC E3 Ubiquitin Ligases in Tumorigenesis
Authors
Series Title
SpringerBriefs in Cancer Research
Copyright
2014
Publisher
Springer International Publishing
Copyright Holder
The Author(s)
eBook ISBN
978-3-319-05026-3
DOI
10.1007/978-3-319-05026-3
Softcover ISBN
978-3-319-05025-6
Edition Number
1
Number of Pages
V, 118
Number of Illustrations and Tables
11 illustrations in colour
Topics