Current Advances in Osteosarcoma

Editors: Kleinerman, Eugenie S. (Ed.)

  • The volume comprehensively covers the biology of osteosarcoma, including seminal discoveries of molecular pathways and genetic alterations that lead to metastasis
  • The topics provide a starting block for unified discussions for osteosarcoma researchers in order to move the field forward
  • The volume editor is an internationally recognized leader in the field of sarcomas, particularly osteosarcoma
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eBook $159.00
price for USA (gross)
  • ISBN 978-3-319-04843-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-3-319-04842-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-3-319-34459-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Current Advances in Osteosarcoma edited by Dr. Eugenie S. Kleinerman summarizes molecular and genetic characteristics, new therapeutic ideas, and biological characteristics that have been uncovered in the past 10 years. Osteosarcoma is an aggressive malignant neoplasm and it is also the most common histological form of bone cancer. It accounts for approximately 56% of new bone tumors, making it the most primary malignant bone tumor in children and adolescents. The lungs are the most common site of metastases and once osteosarcoma spreads to the lungs, it is very difficult to treat. To improve the outcome of this disease, the biology of osteosarcoma needs to be better understood. There are numerous investigators around the world who have made seminal discoveries about the important molecular pathways and genetic alterations that contribute to the development and metastases of osteosarcoma. Other investigators have proposed novel therapeutic strategies including some based on the molecular and genetic phenotype of the disease. Current Advances in Osteosarcoma summarizes all of these new discoveries in one singular text, which will help move the field forward.

About the authors

Eugenie S. Kleinerman, M.D. is Professor and Head of the Division of Pediatrics, the first women Division Head at MD Anderson Cancer Center. She is board certified in pediatrics, holds the Mosbacher Pediatrics Chair and is also a Professor of Cancer Biology. Dr. Kleinerman is internationally recognized for her scientific and clinical expertise in sarcomas, particularly osteosarcoma. She pioneered the use of a unique immunotherapy agent liposome-encapsulated MTP-PE, for children with unresponsive relapsed osteosarcoma lung metastases. Dr. Kleinerman has served on numerous NCI study sections and was a prior member of an FDA advisory panel. She has authored over 177 articles and 21 book chapters and has received over 2900 citations. In 2006, her achievements were recognized by her alma mater, Duke University Medical Center, where she received the Distinguished Medical Alumnus Award. She is the 2009 recipient of the Faculty Achievement Award in Clinical Research.

Reviews

From the book reviews:

“The work is both relevant and timely as no other book fills this particular niche in the field of osteosarcoma. … book is written for students, clinicians, and scientists seeking a review of the biology of osteosarcoma. … Graduate students, medical residents and fellows, and postdoctoral researchers beginning osteosarcoma research projects will find it a very useful introduction to the broad scope of osteosarcoma science. … a worthy addition to the library of all who are interested in osteosarcoma science.” (George Calvert, Doody’s Book Reviews, February, 2015)

Table of contents (20 chapters)

  • Historical Perspective on the Introduction and Use of Chemotherapy for the Treatment of Osteosarcoma

    Jaffe, Norman

    Pages 1-30

  • Wnt Signaling in Osteosarcoma

    Lin, Carol H. (et al.)

    Pages 33-45

  • Receptor Tyrosine Kinases in Osteosarcoma: Not Just the Usual Suspects

    Rettew, Ashley N. (et al.)

    Pages 47-66

  • Understanding the Role of Notch in Osteosarcoma

    McManus, Madonna M. (et al.)

    Pages 67-92

  • Developmental Pathways Hijacked by Osteosarcoma

    Mortus, Jared R. (et al.)

    Pages 93-118

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-3-319-04843-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-3-319-04842-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-3-319-34459-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Current Advances in Osteosarcoma
Editors
  • Eugenie S. Kleinerman
Copyright
2014
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland 2014
eBook ISBN
978-3-319-04843-7
DOI
10.1007/978-3-319-04843-7
Hardcover ISBN
978-3-319-04842-0
Softcover ISBN
978-3-319-34459-1
Edition Number
1
Number of Pages
XII, 359
Number of Illustrations and Tables
11 b/w illustrations, 54 illustrations in colour
Topics