Contributions to Statistics

Statistical Modelling in Biostatistics and Bioinformatics

Selected Papers

Editors: MacKenzie, Gilbert, Peng, Defen (Eds.)

  • Presents new implications for statistical analyses of frailty survival models with structural dispersion
  • Features new methods of model-based clustering in Bioinformatics as well as of detecting genetic sweeps in population genetics
  • Provides new insights into non-proportional hazards survival models and the use of H-likelihood methods
  • Presents results on the new class of HGLMs - hierarchical generalized non-linear models
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  • ISBN 978-3-319-35764-5
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About this book

This book presents selected papers on statistical model development related mainly to the fields of Biostatistics and Bioinformatics. The coverage of the material falls squarely into the following categories: (a) Survival analysis and multivariate survival analysis, (b) Time series and longitudinal data analysis, (c) Statistical model development and (d) Applied statistical modelling. Innovations in statistical modelling are presented throughout each of the four areas, with some intriguing new ideas on hierarchical generalized non-linear models and on frailty models with structural dispersion, just to mention two examples. The contributors include distinguished international statisticians such as Philip Hougaard, John Hinde, Il Do Ha, Roger Payne and Alessandra Durio, among others, as well as promising newcomers. Some of the contributions have come from researchers working in the BIO-SI research programme on Biostatistics and Bioinformatics, centred on the Universities of Limerick and Galway in Ireland and funded by the Science Foundation Ireland under its Mathematics Initiative.

About the authors

Professor Gilbert MacKenzie has a research background in Epidemiology, Biostatistics and Mathematical Statistics. His current research interests include multivariate survival modelling, frailty modelling and covariance modelling. He has published a wide range of research papers and reports and is a past President of the Irish Statistical Association. He holds an adjunct Professorship in Statistics in the University of Limerick and was a visiting Professor in Statistics at ENSAI, France, from 2010 to 2011.

Professor Defen Peng was a visiting Professor in Statistics and senior Research Fellow in the BIO-SI research programme at Limerick from 2009 to 2010. Professor Peng originally worked in the field of Economics at Zhongnan University of Economics and Law, PRC. She has published widely and is currently pursuing several areas of Statistics, such as: survival analysis with frailty, bivariate survival analysis, and the stability of regression models with categorical covariates.

Reviews

From the book reviews:

“The book under review consists of four parts covering survival analysis (Chapters 1–4), longitudinal modeling and time series (Chapters 5–7), statistical model development (Chapters 8–11) and applied statistical modeling (Chapters 12–14). … the variety of topics make it a must-have for a computational biology/bioinformatics lab.” (Irina Ioana Mohorianu, zbMATH, Vol. 1295, 2014)

Table of contents (15 chapters)

  • Introduction

    MacKenzie, Gilbert (et al.)

    Pages 1-6

  • Multivariate Interval-Censored Survival Data: Parametric, Semi-parametric and Non-parametric Models

    Hougaard, Philip

    Pages 9-21

  • Multivariate Survival Models Based on the GTDL

    MacKenzie, Gilbert (et al.)

    Pages 23-34

  • Frailty Models with Structural Dispersion

    Lynch, Joseph (et al.)

    Pages 35-44

  • Random Effects Ordinal Time Models for Grouped Toxicological Data from a Biological Control Assay

    Martinez, Marie-José (et al.)

    Pages 45-58

Buy this book

eBook $84.99
price for USA (gross)
  • ISBN 978-3-319-04579-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $109.00
price for USA
  • ISBN 978-3-319-04578-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $109.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: October 7, 2016
  • ISBN 978-3-319-35764-5
  • Free shipping for individuals worldwide
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Statistical Modelling in Biostatistics and Bioinformatics
Book Subtitle
Selected Papers
Editors
  • Gilbert MacKenzie
  • Defen Peng
Series Title
Contributions to Statistics
Copyright
2014
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
Distribution Rights
Distribution rights for India: Researchco Book Centre, New Delhi, India
eBook ISBN
978-3-319-04579-5
DOI
10.1007/978-3-319-04579-5
Hardcover ISBN
978-3-319-04578-8
Softcover ISBN
978-3-319-35764-5
Series ISSN
1431-1968
Edition Number
1
Number of Pages
XIV, 244
Number of Illustrations and Tables
46 b/w illustrations, 2 illustrations in colour
Topics